Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia

• Published in: The Journal of experimental medicine Vol. 217; no. 4
• Main Authors: Tang, Juan, Tu, Sha, Lin, Guoxin, Guo, Hui, Yan, Chengkai, Liu, Qingjun, Huang, Ling, Tang, Na, Xiao, Yizhi, Pope, R. Marshall, Rajaram, Murugesan V.S., Amer, Amal O., Ahmer, Brian M., Gunn, John S., Wozniak, Daniel J., Tao, Lijian, Coppola, Vincenzo, Zhang, Liwen, Langdon, Wallace Y., Torrelles, Jordi B., Lipkowitz, Stanley, Zhang, Jian
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 06.04.2020
• Subjects: Innate Immunity and Inflammation
• ISSN: 0022-1007; 1540-9538; 1540-9538
• DOI: 10.1084/jem.20182091

Aberrant NLRP3 inflammasome activation contributes to the development of endotoxemia. The importance of negative regulation of NLRP3 inflammasomes remains poorly understood. Here, we show that the E3 ubiquitin ligase Cbl-b is essential for preventing endotoxemia induced by a sub-lethal dose of LPS v...