Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition

• Published in: Brain (London, England : 1878) Vol. 140; no. 3; pp. aww334 - 763
• Main Authors: Pontecorvo, Michael J., Devous, Michael D., Navitsky, Michael, Lu, Ming, Salloway, Stephen, Schaerf, Frederick W., Jennings, Danna, Arora, Anupa K., McGeehan, Anne, Lim, Nathaniel C., Xiong, Hui, Joshi, Abhinay D., Siderowf, Andrew, Mintun, Mark A.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.03.2017
• Subjects: Adult; Aged; Aged, 80 and over; Alzheimer Disease - diagnostic imaging; Amyloid - metabolism; Amyloid beta-Peptides - metabolism; Analysis of Variance; Aniline Compounds - pharmacokinetics; Brain - diagnostic imaging; Brain - drug effects; Brain - metabolism; Cognitive Dysfunction - diagnostic imaging; Cross-Sectional Studies; Ethylene Glycols - pharmacokinetics; Female; Humans; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Original; Positron-Emission Tomography; Radiopharmaceuticals - pharmacokinetics; tau Proteins - metabolism; Young Adult; 18F-AV-1451; flortaucipir; florbetapir; tau; PET

The advent of tau-targeted positron emission tomography tracers such as flortaucipir (18F-AV-1451, also known as 18F-T807) have made it possible to investigate the sequence of development of tau and amyloid-β in relationship to age, and to the development of cognitive impairment due to Alzheimer...