Long-term culture of human lung adenocarcinoma A549 cells enhances the replication of human influenza A viruses

• Published in: Journal of general virology Vol. 100; no. 10; pp. 1345 - 1349
• Main Authors: Ujie, Michiko, Takada, Kosuke, Kiso, Maki, Sakai-Tagawa, Yuko, Ito, Mutsumi, Nakamura, Kazuya, Watanabe, Shinji, Imai, Masaki, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: England Microbiology Society 01.10.2019
• Subjects: Short Communication; replication; long-term culture; A549 cells; Human influenza A viruses

Long-term culture of the human lung adenocarcinoma cell line A549 promotes the differentiation of these cells toward an alveolar type II cell phenotype. Here, we evaluated the susceptibility of long-term cultured A549 cells to human influenza viruses. A549 cells were cultured continuously for 25 day...