Syrian Hamster as an Animal Model for the Study of Human Influenza Virus Infection

• Published in: Journal of virology Vol. 92; no. 4
• Main Authors: Iwatsuki-Horimoto, Kiyoko, Nakajima, Noriko, Ichiko, Yurie, Sakai-Tagawa, Yuko, Noda, Takeshi, Hasegawa, Hideki, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 15.02.2018
• Subjects: Animals; Antibodies, Viral - blood; Disease Models, Animal; Dogs; Epithelium - pathology; Female; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Madin Darby Canine Kidney Cells; Mesocricetus - virology; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Orthomyxoviridae Infections - pathology; Pathogenesis and Immunity; Respiratory System - pathology; Respiratory System - virology; influenza; animal model; hamster

Ferrets and mice are frequently used as animal models for influenza research. However, ferrets are demanding in terms of housing space and handling, whereas mice are not naturally susceptible to infection with human influenza A or B viruses. Therefore, prior adaptation of human viruses is required f...