Design, synthesis, and biological evaluation of ACF-03: a novel anti-fibrotic and antioxidant agent targeting ROS-TGF-β1-HIF-1α axis - Abeysiriwardhana, Hiruni Nilshi Indeevarie; Choi, Jin-Hyuk; Anandappa, Joshua Miguel; Malla, Ayusha; Cho, Moonjae (Applied biological chemistry, 2025)
Keywords: ACF-03; Antifibrotic therapy; antioxidant activity; Antioxidants; Applied Microbiology; Biocompatibility; biological assessment; Biological Techniques; Bioorganic Chemistry; blood proteins; Blood-brain barrier; Cell culture; Chemistry; Chemistry and Materials Science; Clinical trials; Collagen (type I); compliance; computer simulation; Connective tissue growth factor; Design analysis; disease progression; Drug development; Drug interaction; Extracellular matrix; Fibroblasts; Fibrosis; Flavonoids; Glycerol; Guaiacol; Hydrogenation; Hypoxia; Hypoxia-inducible factor 1a; In vivo methods and tests; IPF; Lung diseases; moieties; Oxidative stress; permeability; Pharmacokinetics; Pharmacology; Pulmonary fibrosis; renal clearance; ROS-TGF-β1-HIF-1α axis; Synthesis; therapeutics; Toxicity; Transforming growth factor-b1; Vascular endothelial growth factor; 농학; United States--US; Oxidative stress; Antifibrotic therapy; ROS-TGF-β1-HIF-1α axis; IPF; ACF-03