A20/TNFAIP3 Regulates the DNA Damage Response and Mediates Tumor Cell Resistance to DNA-Damaging Therapy

• Published in: Cancer research (Chicago, Ill.) Vol. 78; no. 4; pp. 1069 - 1082
• Main Authors: Yang, Chuanzhen, Zang, Weicheng, Tang, Zefang, Ji, Yapeng, Xu, Ruidan, Yang, Yongfeng, Luo, Aiping, Hu, Bin, Zhang, Zemin, Liu, Zhihua, Zheng, Xiaofeng
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research, Inc 15.02.2018
• Subjects: Breast cancer; Breast carcinoma; Cancer; Chemotherapy; Clonal deletion; Damage prevention; Deoxyribonucleic acid; Dismantling; DNA; DNA damage; DNA repair; Editing; Enzymatic activity; Enzymes; Error detection; Genomes; Histone H2A; Homologous recombination; Homology; Inflammation; Interfaces; Invasiveness; NF-κB protein; Radiation therapy; Ubiquitin; Ubiquitin-protein ligase

A competent DNA damage response (DDR) helps prevent cancer, but once cancer has arisen, DDR can blunt the efficacy of chemotherapy and radiotherapy that cause lethal DNA breakage in cancer cells. Thus, blocking DDR may improve the efficacy of these modalities. Here, we report a new DDR mechanism tha...