Influence of genotype, dose and sex on pruritogen-induced scratching behavior in the mouse

• Published in: Pain (Amsterdam) Vol. 124; no. 1; pp. 50 - 58
• Main Authors: Green, Amanda D., Young, Katrina K., Lehto, Sonya G., Smith, Shad B., Mogil, Jeffrey S.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.09.2006; Elsevier
• Subjects: Analgesics; Analysis of Variance; Animals; Behavior, Animal - drug effects; Biological and medical sciences; Chloroquine; Chloroquine - administration & dosage; Chloroquine - analogs & derivatives; Dose-Response Relationship, Drug; Female; Fundamental and applied biological sciences. Psychology; Genetic; Genotype; Histamine; Histamine - administration & dosage; Injections, Subcutaneous; Irritants - administration & dosage; Itch; Male; Medical sciences; Mice; Mice, Inbred Strains; Neuropharmacology; Pharmacology. Drug treatments; Pruritus - chemically induced; Pruritus - genetics; Pruritus - physiopathology; Sex Characteristics; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors; Species Specificity; Strain difference; Vertebrates: nervous system and sense organs; Strain difference; Genetic; Histamine; Itch; Chloroquine; Human; Animal model; Genetic variability; Pathophysiology; Rodentia; Sex; Genotype; Strain; Itching; Vertebrata; Mammalia; Pain; Mouse; Heritability; Behavior

Itch features considerable interindividual variability in humans, and initial studies using animal models have demonstrated a likely role of genetic factors in mediating such variability. In an attempt to systematically study genetic mediation of itch in the mouse such that gene identification by li...