Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau

• Published in: The Journal of experimental medicine Vol. 215; no. 9; pp. 2235 - 2245
• Main Authors: Kang, Silvia S., Ebbert, Mark T.W., Baker, Kelsey E., Cook, Casey, Wang, Xuewei, Sens, Jonathon P., Kocher, Jeanne-Pierre, Petrucelli, Leonard, Fryer, John D.
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 03.09.2018
• Subjects: Aging - genetics; Aging - immunology; Aging - pathology; Alzheimer Disease - genetics; Alzheimer Disease - immunology; Alzheimer Disease - pathology; Amyloid - genetics; Amyloid - immunology; Amyloidosis - genetics; Amyloidosis - immunology; Amyloidosis - pathology; Animals; Apolipoproteins E - genetics; Apolipoproteins E - immunology; Chemokine CCL3 - genetics; Chemokine CCL3 - immunology; Chemokine CCL4 - genetics; Chemokine CCL4 - immunology; Disease Models, Animal; Female; Male; Mice; Mice, Transgenic; Microglia - immunology; Microglia - pathology; Signal Transduction - genetics; Signal Transduction - immunology; tau Proteins - genetics; tau Proteins - immunology

Alzheimer’s disease (AD) is an age-associated neurodegenerative disease characterized by amyloidosis, tauopathy, and activation of microglia, the brain resident innate immune cells. We show that a RiboTag translational profiling approach can bypass biases due to cellular enrichment/cell sorting. Usi...