VP1 Amino Acid Residue 145 of Enterovirus 71 Is a Key Residue for Its Receptor Attachment and Resistance to Neutralizing Antibody during Cynomolgus Monkey Infection

• Published in: Journal of virology Vol. 92; no. 15
• Main Authors: Fujii, Ken, Sudaka, Yui, Takashino, Ayako, Kobayashi, Kyousuke, Kataoka, Chikako, Suzuki, Tadaki, Iwata-Yoshikawa, Naoko, Kotani, Osamu, Ami, Yasushi, Shimizu, Hiroyuki, Nagata, Noriyo, Mizuta, Katsumi, Matsuzaki, Yoko, Koike, Satoshi
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.08.2018
• Subjects: Pathogenesis and Immunity; Spotlight; pathogenesis; neutralizing antibodies; animal models; enterovirus

The contribution of VP1-145 variants in humans is not fully understood. In some studies, VP1-145G/Q viruses were isolated more frequently from severely affected patients than from mildly affected patients, suggesting that VP1-145G/Q viruses are more virulent. In the accompanying paper (K. Kobayashi,...