Hepatitis B Virus Precore Protein p22 Inhibits Alpha Interferon Signaling by Blocking STAT Nuclear Translocation

• Published in: Journal of virology Vol. 93; no. 13
• Main Authors: Mitra, Bidisha, Wang, Jinyu, Kim, Elena S., Mao, Richeng, Dong, Minhui, Liu, Yuanjie, Zhang, Jiming, Guo, Haitao
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.07.2019
• Subjects: Adolescent; Adult; Antiviral Agents - pharmacology; Carcinoma, Hepatocellular - metabolism; Female; HEK293 Cells; Hep G2 Cells; Hepatitis B - virology; Hepatitis B Core Antigens - metabolism; Hepatitis B e Antigens - metabolism; Hepatitis B virus - genetics; Hepatitis B virus - pathogenicity; Hepatitis B, Chronic; Humans; Immunity, Innate; Interferon-alpha - metabolism; Liver; Liver Neoplasms - metabolism; Male; Middle Aged; Protein Transport; Signal Transduction - drug effects; STAT1 Transcription Factor - metabolism; Viral Core Proteins - metabolism; Virus-Cell Interactions; Young Adult; hepatitis B virus; interferons

Chronic hepatitis B virus (HBV) infection continues to be a major global health concern, and patients who fail to mount an efficient immune response to clear the virus will develop a life-long chronic infection that can progress to chronic active hepatitis, cirrhosis, and primary hepatocellular carc...