Interleukin-1 receptor antagonist modifies the changes in vital organs induced by acute necrotizing pancreatitis in a rat experimental model

• Published in: Critical care medicine Vol. 23; no. 5; p. 901
• Main Authors: Tanaka, N, Murata, A, Uda, K, Toda, H, Kato, T, Hayashida, H, Matsuura, N, Mori, T
• Format: Journal Article
• Language: English
• Published: United States 01.05.1995
• Subjects: Acute Disease; Animals; Deoxycholic Acid; Disease Models, Animal; Drug Evaluation, Preclinical; Interleukin 1 Receptor Antagonist Protein; Interleukin-1 - administration & dosage; Male; Multiple Organ Failure - drug therapy; Multiple Organ Failure - etiology; Necrosis; Pancreas - pathology; Pancreatitis - chemically induced; Pancreatitis - complications; Pancreatitis - drug therapy; Prospective Studies; Random Allocation; Rats; Rats, Wistar; Receptors, Interleukin-1 - antagonists & inhibitors; Receptors, Interleukin-1 - drug effects; Recombinant Proteins - administration & dosage; Sialoglycoproteins - administration & dosage; Specific Pathogen-Free Organisms

Interleukin-1 (IL-1) is a mediator in some critical conditions such as septic shock and multiple organ failure. Acute pancreatitis is one of the noted causes of multiple organ failure but the mechanism by which local inflammation progresses to systemic disease is unknown. In this study, we used an I...