Assessment of Leydig and Sertoli Cell Functions in Infants with Nonmosaic Klinefelter Syndrome: Insulin-Like Peptide 3 Levels Are Normal and Positively Correlated with LH Levels

• Published in: The journal of clinical endocrinology and metabolism Vol. 96; no. 4; pp. E746 - E753
• Main Authors: Cabrol, Sylvie, Ross, Judith L., Fennoy, Ilene, Bouvattier, Claire, Roger, Marc, Lahlou, Najiba
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.04.2011; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Anti-Mullerian Hormone - analysis; Anti-Mullerian Hormone - blood; Beta cells; Child, Preschool; Cohort Studies; Diagnostic Techniques, Endocrine; Follicle Stimulating Hormone - analysis; Follicle Stimulating Hormone - blood; Follicle-stimulating hormone; Germ cells; Humans; Infant; Infant, Newborn; Infants; Infertility; Inhibin; Inhibins - analysis; Inhibins - blood; Insulin; Insulin - analysis; Insulin - blood; JCEM Online: Advances in Genetics; Karyotypes; Klinefelter Syndrome - blood; Klinefelter Syndrome - diagnosis; Klinefelter Syndrome - genetics; Klinefelter Syndrome - physiopathology; Klinefelter's syndrome; Leydig cells; Leydig Cells - physiology; Luteinizing hormone; Luteinizing Hormone - analysis; Luteinizing Hormone - blood; Male; Mosaicism; Pediatrics; Peptides; Proteins - analysis; Puberty; Secretions; Sertoli Cells - physiology; Sex chromosomes; Testosterone; Testosterone - analysis; Testosterone - blood; Tubules

Context:Klinefelter syndrome (KS) is the most common sex chromosome disorder and a major cause of male infertility. In adult patients, serum inhibin B and anti-Mullerian-hormone (AMH) are undetectable, testosterone secretion is often impaired, and the tubules are depleted of germ cells. Before puber...