Citrus Polyphenol Hesperidin Stimulates Production of Nitric Oxide in Endothelial Cells while Improving Endothelial Function and Reducing Inflammatory Markers in Patients with Metabolic Syndrome

• Published in: The journal of clinical endocrinology and metabolism Vol. 96; no. 5; pp. E782 - E792
• Main Authors: Rizza, Stefano, Muniyappa, Ranganath, Iantorno, Micaela, Kim, Jeong-a, Chen, Hui, Pullikotil, Philomena, Senese, Nicoletta, Tesauro, Manfredi, Lauro, Davide, Cardillo, Carmine, Quon, Michael J.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.05.2011; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Adenylate Kinase - metabolism; AKT protein; Amyloid; Animals; C-reactive protein; Cattle; Cell Adhesion - drug effects; Cell adhesion molecules; Cell culture; Cells, Cultured; Clinical trials; Cross-Over Studies; Double-Blind Method; E-selectin; Endothelial cells; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Endothelium; Endothelium, Vascular - physiology; Female; Flavonoids; Hesperidin; Hesperidin - pharmacology; Hot Topics in Translational Endocrinology; Humans; Hydrogen peroxide; Inflammation; Inflammation - metabolism; Kinases; Male; Metabolic syndrome; Metabolic Syndrome - metabolism; Metabolites; Middle Aged; Monocytes; Monocytes - drug effects; Nitric oxide; Nitric Oxide - biosynthesis; Nitric Oxide Synthase Type III - metabolism; Nitric-oxide synthase; Oncogene Protein v-akt - metabolism; Phosphorylation; Placebos; Signal Transduction - drug effects; Stimulation, Chemical; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor Necrosis Factor-alpha - pharmacology; Tumor necrosis factor-α; Vascular cell adhesion molecule 1; Vasodilation - physiology

Context:Hesperidin, a citrus flavonoid, and its metabolite hesperetin may have vascular actions relevant to their health benefits. Molecular and physiological mechanisms of hesperetin actions are unknown.Objective:We tested whether hesperetin stimulates production of nitric oxide (NO) from vascular...