Citrus Polyphenol Hesperidin Stimulates Production of Nitric Oxide in Endothelial Cells while Improving Endothelial Function and Reducing Inflammatory Markers in Patients with Metabolic Syndrome - Rizza, Stefano; Muniyappa, Ranganath; Iantorno, Micaela; Kim, Jeong-a; Chen, Hui; Pullikotil, Philomena; Senese, Nicoletta; Tesauro, Manfredi; Lauro, Davide; Cardillo, Carmine; Quon, Michael J. (The journal of clinical endocrinology and metabolism, 2011)
Keywords: Adenylate Kinase - metabolism; AKT protein; Amyloid; Animals; C-reactive protein; Cattle; Cell Adhesion - drug effects; Cell adhesion molecules; Cell culture; Cells, Cultured; Clinical trials; Cross-Over Studies; Double-Blind Method; E-selectin; Endothelial cells; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Endothelium; Endothelium, Vascular - physiology; Female; Flavonoids; Hesperidin; Hesperidin - pharmacology; Hot Topics in Translational Endocrinology; Humans; Hydrogen peroxide; Inflammation; Inflammation - metabolism; Kinases; Male; Metabolic syndrome; Metabolic Syndrome - metabolism; Metabolites; Middle Aged; Monocytes; Monocytes - drug effects; Nitric oxide; Nitric Oxide - biosynthesis; Nitric Oxide Synthase Type III - metabolism; Nitric-oxide synthase; Oncogene Protein v-akt - metabolism; Phosphorylation; Placebos; Signal Transduction - drug effects; Stimulation, Chemical; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor Necrosis Factor-alpha - pharmacology; Tumor necrosis factor-α; Vascular cell adhesion molecule 1; Vasodilation - physiology