Hyperhomocysteinemia Exaggerates Adventitial Inflammation and Angiotensin II−Induced Abdominal Aortic Aneurysm in Mice

• Published in: Circulation research Vol. 111; no. 10; pp. 1261 - 1273
• Main Authors: Liu, Ziyi, Luo, Hongzhi, Zhang, Lu, Huang, Yaqian, Liu, Bo, Ma, Kongyang, Feng, Juan, Xie, Jinsheng, Zheng, Jingang, Hu, Jing, Zhan, Siyan, Zhu, Yi, Xu, Qingbo, Kong, Wei, Wang, Xian
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 26.10.2012; Lippincott Williams & Wilkins
• Subjects: Adventitia - immunology; Angiotensin II - pharmacology; Animals; Aortic Aneurysm, Abdominal - chemically induced; Aortic Aneurysm, Abdominal - epidemiology; Aortic Aneurysm, Abdominal - immunology; Apolipoproteins E - genetics; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Chemokine CCL2 - secretion; Disease Models, Animal; Diseases of the aorta; Female; Fibroblasts - enzymology; Fibroblasts - immunology; Fibroblasts - secretion; Fundamental and applied biological sciences. Psychology; Humans; Hyperhomocysteinemia - epidemiology; Hyperhomocysteinemia - immunology; Hyperhomocysteinemia - metabolism; Incidence; Interleukin-6 - secretion; Male; Medical sciences; Mice; Mice, Mutant Strains; Middle Aged; NADPH Oxidase 4; NADPH Oxidases - metabolism; Reactive Oxygen Species - metabolism; Risk Factors; Signal Transduction - immunology; Smad2 Protein - metabolism; Smad3 Protein - metabolism; Vasculitis - epidemiology; Vasculitis - immunology; Vasculitis - metabolism; Vasoconstrictor Agents - pharmacology; Vertebrates: cardiovascular system; NADPH; Enzyme; Peptide hormone; Rodentia; Oxidase; Cardiovascular disease; Inflammation; Aortic aneurysm; abdominal aortic aneurysm; Octapeptide; Renin angiotensin system; Vertebrata; adventitial fibroblast; Mammalia; Mouse; NADPH oxidase 4; Hyperhomocysteinemia; Oxidoreductases; Circulatory system; Angiotensin II; Fibroblast

RATIONALE:A number of epidemiological studies have suggested an association of hyperhomocysteinemia (HHcy) and abdominal aortic aneurysm (AAA), but discrepancies exist. In addition, we lack direct evidence supporting a causal role. OBJECTIVE:We determined the association and contribution of HHcy to...