Preventing the Progression of Intestinal Failure-Associated Liver Disease in Infants Using a Composite Lipid Emulsion: A Pilot Randomized Controlled Trial of SMOFlipid

• Published in: JPEN. Journal of parenteral and enteral nutrition Vol. 41; no. 5; p. 866
• Main Authors: Diamond, Ivan R, Grant, Robert C, Pencharz, Paul B, de Silva, Nicole, Feldman, Brian M, Fitzgerald, Peter, Sigalet, David, Dicken, Bryan, Turner, Justine, Marchand, Valerie, Ling, Simon C, Moore, Aideen M, Avitzur, Yaron, Wales, Paul W
• Format: Journal Article
• Language: English
• Published: United States 01.07.2017
• Subjects: Bilirubin - blood; Emulsions - therapeutic use; Fat Emulsions, Intravenous - therapeutic use; Female; Humans; Infant; Infant, Newborn; Intestinal Diseases - complications; Intestinal Diseases - therapy; Intestines - drug effects; Intestines - metabolism; Liver Diseases - complications; Liver Diseases - therapy; Male; Parenteral Nutrition, Total; Phospholipids - therapeutic use; Pilot Projects; Soybean Oil - therapeutic use; Treatment Outcome; intestinal failure associated liver disease; intestinal failure; clinical trials; ω-3 fatty acids; intravenous lipid emulsions

To examine whether SMOFlipid prevents progression of intestinal failure-associated liver disease (IFALD) in parenteral nutrition (PN)-dependent infants with early IFALD (conjugated bilirubin 17-50 µmol/L, 1-3 mg/dL). Pilot multicenter blinded randomized controlled trial comparing SMOFlipid with Intr...