Effects of Varenicline on Ethanol- and Food-Maintained Responding in a Concurrent Access Procedure

• Published in: Alcoholism, clinical and experimental research Vol. 37; no. 7; pp. 1228 - 1233
• Main Authors: Ginsburg, Brett C., Lamb, Richard J.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.07.2013
• Subjects: Alcohol; Alcohol Drinking - drug therapy; Alcohol Drinking - psychology; Alcoholism; Animals; Benzazepines - pharmacology; Benzazepines - therapeutic use; Conditioning, Operant - drug effects; Conditioning, Operant - physiology; Dose-Response Relationship, Drug; Eating - drug effects; Eating - physiology; Eating - psychology; Ethanol - administration & dosage; Male; Nicotine; Nicotinic Agonists - pharmacology; Nicotinic Agonists - therapeutic use; Operant; Quinoxalines - pharmacology; Quinoxalines - therapeutic use; Rats; Rats, Inbred Lew; Self Administration; Treatment Outcome; Varenicline; Alcohol; Alcoholism; Operant; Nicotine

Background Varenicline has been reported to reduce drinking in smokers and to selectively decrease responding for ethanol (EtOH) versus alternatives in preclinical studies. Such selectivity may reflect potential therapeutic effects and the involvement of nicotinic receptors in EtOH reinforcement. Ho...