Dearomatization‐Rearomatization Strategy for ortho‐Selective Alkylation of Phenols with Primary Alcohols

• Published in: Angewandte Chemie International Edition Vol. 60; no. 8; pp. 4043 - 4048
• Main Authors: Yu, Jianjin, Li, Chao‐Jun, Zeng, Huiying
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 19.02.2021; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Alcohol; Alcohols; Alkylation; aromaticity; Chemical reactions; Chemical synthesis; Chemistry; Chemistry, Multidisciplinary; cross-coupling; Palladium; Phenols; Physical Sciences; Polymers; reaction mechanisms; Science & Technology; Substitutes; synthetic methods; SUBSTITUTION; ETHERS; ANNULATION; CONVERSION; ARENES; cross-coupling; reaction mechanisms; palladium; ORTHO-ARYLATION; synthetic methods; ALKENYLATION; aromaticity

Phenols are common precursors and core structures of a variety of industrial chemicals ranging from pharmaceuticals to polymers. However, the synthesis of site‐specifically substituted phenols is challenging, and thus the development of new methods for this purpose would be highly desirable. Reporte...