L-687, 781, A NEW MEMBER OF THE PAPULACANDIN FAMILY OF β-1, 3-D-GLUCAN SYNTHESIS INHIBITORS I. FERMENTATION, ISOLATION, AND BIOLOGICAL ACTIVITY

• Published in: Journal of antibiotics Vol. 44; no. 1; pp. 45 - 51
• Main Authors: VANMIDDLESWORTH, FRANK, OMSTEAD, MARY NALLIN, SCHMATZ, DENNIS, BARTIZAL, KEN, FROMTLING, ROBERT, BILLS, GERALD, NOLLSTADT, KARL, HONEYCUTT, SUSAN, ZWEERINK, MARCIA, GARRITY, GEORGE, WILSON, KEN
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1991; Japan Antibiotics Research Association
• Subjects: Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal agents; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Antifungal Agents - therapeutic use; beta-Glucans; Biological and medical sciences; Candida - drug effects; Candidiasis - drug therapy; Cryptococcus neoformans - drug effects; Disease Models, Animal; Fermentation; Fungi - drug effects; Glucans - antagonists & inhibitors; Glucans - biosynthesis; Male; Medical sciences; Mice; Mitosporic Fungi - classification; Mitosporic Fungi - metabolism; Pharmacology. Drug treatments; Pneumocystis carinii; Pneumonia, Pneumocystis - drug therapy; Pyrans - isolation & purification; Pyrans - pharmacology; Pyrans - therapeutic use; Rats; Rats, Inbred Strains; Glucan; Protozoa; Antifungal agent; Production; Isolation; Pneumocystis carinii; Inhibition; Microorganism; Antibacterial agent; Fermentation; Sporozoa; Biological activity
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.44.45

A new β-1, 3-D-glucan synthesis inhibitor, L-687, 781 is produced by the cultivation of Dictyochaeta simplex ATCC 20960. L-687, 781 exhibits potent in vitro antifungal activity as well as anti-Pneumocystis activity in a rat model.