Simultaneous comprehensive multiplex autoantibody analysis for rapidly progressive glomerulonephritis

• Published in: Medicine (Baltimore) Vol. 95; no. 44; p. e5225
• Main Authors: Sowa, Mandy, Trezzi, Barbara, Hiemann, Rico, Schierack, Peter, Grossmann, Kai, Scholz, Juliane, Somma, Valentina, Sinico, Renato Alberto, Roggenbuck, Dirk, Radice, Antonella
• Format: Journal Article
• Language: English
• Published: United States The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved 01.11.2016; Wolters Kluwer Health
• Subjects: Adult; Aged; Antibodies, Antineutrophil Cytoplasmic - analysis; Case-Control Studies; Child, Preschool; Diagnostic Accuracy Study; Disease Progression; Female; Fluorescent Antibody Technique, Indirect; Glomerulonephritis - blood; Glomerulonephritis - immunology; Humans; Male; Middle Aged; Neutrophils - chemistry; Time Factors

Rapidly progressive glomerulonephritis (RPGN) is mainly caused by anti-glomerular basement membrane (GBM) antibody-mediated glomerulonephritis, immune-complex or anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides and leads to rapid loss of renal function. Detection of ANCA and autoa...