Toll-like receptors-2 and -9 (TLR2 and TLR9) gene polymorphism in patients with type 2 diabetes and diabetic foot

• Published in: Medicine (Baltimore) Vol. 96; no. 17; p. e6760
• Main Authors: Wifi, Mohamed-Naguib Abdalla, Assem, Maha, Elsherif, Rasha Hamed, El-Azab, Hameda Abdel-Fattah, Saif, Aasem
• Format: Journal Article
• Language: English
• Published: United States The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved 01.04.2017; Wolters Kluwer Health
• Subjects: Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - genetics; Diabetic Foot - drug therapy; Diabetic Foot - genetics; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Genotyping Techniques; Humans; Male; Middle Aged; Observational Study; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Toll-Like Receptor 2 - genetics; Toll-Like Receptor 9 - genetics

Toll-like receptors (TLRs) are innate immune receptors that mediate the inflammatory response in diabetes mellitus (DM). The aim of this study is to evaluate the association of TLR2 and TLR9 gene polymorphism in patients with type 2 DM (T2DM) and diabetic foot (DF).The study included 90 subjects div...