Lipid Emulsion Formulation of Parenteral Nutrition Affects Intestinal Microbiota and Host Responses in Neonatal Piglets

• Published in: JPEN. Journal of parenteral and enteral nutrition Vol. 41; no. 8; p. 1301
• Main Authors: Lavallee, Celeste M, MacPherson, Jayden A R, Zhou, Mi, Gao, Yanhua, Wizzard, Pamela R, Wales, Paul W, Turner, Justine M, Willing, Benjamin P
• Format: Journal Article
• Language: English
• Published: United States 01.11.2017
• Subjects: Animals; Animals, Newborn; Antimicrobial Cationic Peptides - genetics; Antimicrobial Cationic Peptides - metabolism; Cytokines - genetics; Cytokines - metabolism; DNA, Bacterial - isolation & purification; Dysbiosis - diagnosis; Fat Emulsions, Intravenous - administration & dosage; Fat Emulsions, Intravenous - chemistry; Fatty Acids, Omega-3 - administration & dosage; Fatty Acids, Omega-3 - analysis; Fatty Acids, Omega-6 - administration & dosage; Fatty Acids, Omega-6 - analysis; Gastrointestinal Microbiome; Host-Pathogen Interactions; Male; Mucins - genetics; Mucins - metabolism; Parenteral Nutrition Solutions - chemistry; Parenteral Nutrition, Total; RNA, Ribosomal, 16S - isolation & purification; Sequence Analysis, DNA; Swine; Tight Junction Proteins - genetics; Tight Junction Proteins - metabolism; life cycle; research and diseases; liver disease; parenteral nutrition; immune response; nutrition, lipids; neonates; piglet; infant; microbiome

Total parenteral nutrition (TPN) is a cause of intestinal microbial dysbiosis and impaired gut barrier function. This may contribute to life-threatening parenteral nutrition-associated liver disease and sepsis in infants. We compared the effects of a lipid emulsion containing long-chain ω-3 polyunsa...