Rutin antinociception involves opioidergic mechanism and descending modulation of ventrolateral periaqueductal grey matter in rats

• Published in: European journal of pain Vol. 20; no. 2; p. 274
• Main Authors: Hernandez-Leon, A, Fernández-Guasti, A, González-Trujano, M E
• Format: Journal Article
• Language: English
• Published: England 01.02.2016
• Subjects: Animals; Male; Microinjections; Morphine - pharmacology; Morphine - therapeutic use; Naltrexone - pharmacology; Narcotic Antagonists - pharmacology; Narcotics - pharmacology; Narcotics - therapeutic use; Nociception - drug effects; Pain - drug therapy; Pain Measurement; Periaqueductal Gray - drug effects; Rats; Rats, Wistar; Receptors, Opioid - agonists; Rutin - pharmacology; Rutin - therapeutic use; Tramadol - pharmacology; Tramadol - therapeutic use

Rutin is a bioflavonoid found in fruits, vegetables and plants used in traditional medicine to alleviate pain. However, rutin's scientific evidence for the modulation of pain and its mechanism of action is lacking. It is well known that the periaqueductal grey matter (PAG) contains opioidergic...