PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy - Yoshida, Teruhiko; Latt, Khun Zaw; Rosenberg, Avi Z; Santo, Briana A; Myakala, Komuraiah; Ishimoto, Yu; Zhao, Yongmei; Shrivastav, Shashi; Jones, Bryce A; Yang, Xiaoping; Wang, Xiaoxin X; Tutino, Vincent M; et al. (eLife, 2024)
Keywords: AIDS-Associated Nephropathy - genetics; AIDS-Associated Nephropathy - metabolism; AIDS-Associated Nephropathy - pathology; Animals; Approximation; Cell activation; Chronic kidney failure; Creatinine; Cyclin-dependent kinases; Cytoskeleton; Disease Models, Animal; Double-stranded RNA; eIF-2 kinase; eIF-2 Kinase - genetics; eIF-2 Kinase - metabolism; Gene expression; Genes; Genetic engineering; Genomes; HIV; HIV (Viruses); HIV-1 - genetics; HIV-1 - physiology; HIV-associated nephropathy; Human immunodeficiency virus; Humans; Kidney diseases; Kinases; Medicine; Mice; Mice, Transgenic; Mitochondria; Mitochondria - metabolism; Mitochondrial DNA; Morbidity; Nephropathy; Neutrophils; Oxidative phosphorylation; Phenotypes; Phosphorylation; Platelet-derived growth factor; Podocytes - metabolism; Principal components analysis; protein kinase R; Proteins; Proximal tubules; Quantitative analysis; RNA; RNA-seq; Scientific equipment and supplies industry; single-nucleus RNA-seq; Stat3 protein; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Transgenic mice; Canada; United States; California; United States--US; HIV-associated nephropathy; mouse; HIV; RNA-seq; mitochondria; medicine; single-nucleus RNA-seq; protein kinase R