Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis
Leukotrienes, the biologically active metabolites of arachidonic acid, have been implicated in a variety of inflammatory responses, including asthma, arthritis and psoriasis. Recently a compound, MK-886, has been described that blocks the synthesis of leukotrienes in intact activated leukocytes, but...
Saved in:
| Published in | Nature (London) Vol. 343; no. 6255; pp. 282 - 284 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing
18.01.1990
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Leukotrienes, the biologically active metabolites of arachidonic acid, have been implicated in a variety of inflammatory responses, including asthma, arthritis and psoriasis. Recently a compound, MK-886, has been described that blocks the synthesis of leukotrienes in intact activated leukocytes, but has little or no effect on enzymes involved in leukotriene synthesis, including 5-lipoxygenase, in cell-free systems. A membrane protein with a high affinity for MK-886 and possibly representing the cellular target for MK-886 has been isolated from rat and human leukocytes. Here, we report the isolation of a complementary DNA clone encoding the MK-886-binding protein. We also demonstrate that the expression of both the MK-886-binding protein and 5-lipoxygenase is necessary for leukotriene synthesis in intact cells. Because the MK-886-binding protein seems to play a part in activating this enzyme in cells, it is termed the five-lipoxygenase activating protein (FLAP). |
|---|---|
| AbstractList | Leukotrienes, the biologically active metabolites of arachidonic acid, have been implicated in a variety of inflammatory responses, including asthma, arthritis and psoriasis. Recently a compound, MK-886, has been described that blocks the synthesis of leukotrienes in intact activated leukocytes, but has little or no effect on enzymes involved in leukotriene synthesis, including 5-lipoxygenase, in cell-free systems. A membrane protein with a high affinity for MK-886 and possibly representing the cellular target for MK-886 has been isolated from rat and human leukocytes. Here, we report the isolation of a complementary DNA clone encoding the MK-886-binding protein. We also demonstrate that the expression of both the MK-886-binding protein and 5-lipoxygenase is necessary for leukotriene synthesis in intact cells. Because the MK-886-binding protein seems to play a part in activating this enzyme in cells, it is termed the five-lipoxygenase activating protein (FLAP). Recently a compound, MK-886, has been described that blocks the synthesis of leukotrienes in intact activated leukocytes, but has little or no effect on enzymes involved in leukotriene synthesis, including 5-lipoxygenase, in cell-free systems. A membrane protein with a high affinity for MK-886 and possibly representing the cellular target for MK-886 has been isolated from rat and human leukocytes. Here, we report the isolation of a complementary DNA clone encoding the MK-886-binding protein. We also demonstrate that the expression of both the MK-886-binding protein and 5-lipoxygenase is necessary for leukotriene synthesis in intact cells. Because the MK-886-binding protein seems to play a part in activating this enzyme in cells, it is termed the five-lipoxygenase activating protein (FLAP). Recently, a compound, MK-886, has been described that blocks the synthesis of leukotrienes in intact activated leukocytes, but has little or no effect on enzymes involved in leukotriene synthesis, including 5-lipoxygenase, in cell-free systems. The MK-886-binding protein is discussed. LEUKOTRIENES, the biologically active metabolites of arachidonic acid, have been implicated in a variety of inflammatory responses, including asthma, arthritis and psoriasis1,2. Recently a compound, MK-886, has been described that blocks the synthesis of leukotrienes in intact activated leukocytes, but has little or no effect on enzymes involved in leukotriene synthesis, including 5-lipoxygenase, in cell-free systems3. A membrane protein with a high affinity for MK-886 and possibly representing the cellular target for MK-886 has been isolated from rat and human leukocytes4. Here, we report the isolation of a complementary DNA clone encoding the МК-886-binding protein. We also demonstrate that the expression of both the МК-886-binding protein and 5-lipoxygenase is necessary for leukotriene synthesis in intact cells. Because the МК-886-binding protein seems to play a part in activating this enzyme in cells, it is termed the five-lipoxygenase activating protein (FLAP). |
| Author | Diehl, R. E Vickers, P. J Evans, J. F Opas, E Gillard, J. W Miller, D. K Rands, E Dixon, R. A. F |
| Author_xml | – sequence: 1 givenname: R. A. F surname: Dixon fullname: Dixon, R. A. F – sequence: 2 givenname: R. E surname: Diehl fullname: Diehl, R. E – sequence: 3 givenname: E surname: Opas fullname: Opas, E – sequence: 4 givenname: E surname: Rands fullname: Rands, E – sequence: 5 givenname: P. J surname: Vickers fullname: Vickers, P. J – sequence: 6 givenname: J. F surname: Evans fullname: Evans, J. F – sequence: 7 givenname: J. W surname: Gillard fullname: Gillard, J. W – sequence: 8 givenname: D. K surname: Miller fullname: Miller, D. K |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19478659$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/2300173$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkV1rFDEUhoNU6rYK_gFlaPHjZjSfk5PLUvyCBUH0esjOnNTU2WSbZMT992bZdQVBvQi5OA9P3pP3jJyEGJCQx4y-YlTAayEFB27pPbJgUnet7ECfkAWlHFoKontAznK-pZQqpuUpOeWCUqbFgiw_4d3sE64xlCa6xjaqnfwm_tjeYLAZWzsU_90WH26aTYoFfWhcTM2E87dYkseATd6G8hWzzw_JfWenjI8O9zn58vbN5-v37fLjuw_XV8t2kNKU1oExumMa0MHoqOZmpVaD4ljj1cMRtNSDHg2MwjpunFkxOwqAjrmRGxTn5PneWxPdzZhLv_Z5wGmyAeOce206qqRiFXzxb1AKyYUB-K-SKSkVUF3Byz_A2zinUNftOeeGAQO10138laKy_gLQXbqXe2hIMeeErt8kv7Zp2zPa72rtf9Va0ScH37xa43gEDz3W-bPD3ObBTi7ZMPj822ekhk6Zyj3dc8GWOeEROD70E2Nnsv8 |
| CODEN | NATUAS |
| CitedBy_id | crossref_primary_10_1016_j_bcp_2021_114759 crossref_primary_10_1186_s43054_023_00210_w crossref_primary_10_1016_j_brainres_2004_01_018 crossref_primary_10_4049_jimmunol_1001258 crossref_primary_10_1002_jcp_1041600315 crossref_primary_10_1016_S0014_5793_98_01196_X crossref_primary_10_1007_s10822_008_9180_0 crossref_primary_10_1016_j_bbalip_2005_08_015 crossref_primary_10_1128_MCB_19_3_1950 crossref_primary_10_1016_S0889_8561_22_00664_6 crossref_primary_10_1046_j_1525_1381_1999_t01_1_99242_x crossref_primary_10_1067_mai_2000_104382 crossref_primary_10_1038_sj_bjp_0705405 crossref_primary_10_1152_jn_1998_79_3_1230 crossref_primary_10_1158_1078_0432_CCR_05_2149 crossref_primary_10_1165_ajrcmb_26_4_4747 crossref_primary_10_4049_jimmunol_165_7_3592 crossref_primary_10_1016_S0021_9258_19_37121_2 crossref_primary_10_1074_jbc_270_37_21652 crossref_primary_10_1016_S0306_9877_02_00213_X crossref_primary_10_1016_S0889_8561_01_00006_6 crossref_primary_10_4049_jimmunol_170_1_139 crossref_primary_10_1016_j_prostaglandins_2007_01_003 crossref_primary_10_1016_S0223_5234_99_00225_1 crossref_primary_10_1016_j_amjsurg_2010_05_010 crossref_primary_10_1002_1529_0131_200108_44_8_1865__AID_ART325_3_0_CO_2_M crossref_primary_10_1016_S0960_894X_01_81169_0 crossref_primary_10_1073_pnas_1019473108 crossref_primary_10_1159_000355931 crossref_primary_10_1038_s41586_018_0393_7 crossref_primary_10_1136_thx_52_4_342 crossref_primary_10_1007_s00018_019_03393_x crossref_primary_10_1378_chest_111_2_Supplement_27S crossref_primary_10_1016_S0006_2952_96_00832_5 crossref_primary_10_1016_S0021_9258_17_40703_4 crossref_primary_10_1016_S0248_8663_97_83419_4 crossref_primary_10_1002_ppul_20392 crossref_primary_10_1152_ajpheart_00281_2003 crossref_primary_10_1016_0952_3278_93_90211_E crossref_primary_10_1177_1087057113497401 crossref_primary_10_1016_0006_8993_91_90519_2 crossref_primary_10_1177_1087057103260741 crossref_primary_10_1016_0929_7855_95_00018_L crossref_primary_10_1080_10715769900300851 crossref_primary_10_3389_fphar_2019_01337 crossref_primary_10_1152_ajpcell_00296_2004 crossref_primary_10_1111_j_1365_2222_1991_tb01741_x crossref_primary_10_1172_JCI97945 crossref_primary_10_1016_j_mce_2015_09_033 crossref_primary_10_1046_j_1471_4159_1999_0730693_x crossref_primary_10_1038_s41467_018_06158_5 crossref_primary_10_1084_jem_193_1_123 crossref_primary_10_1016_j_prostaglandins_2004_10_002 crossref_primary_10_1111_j_1749_6632_1991_tb37970_x crossref_primary_10_1016_j_bbrc_2022_03_130 crossref_primary_10_1016_j_prostaglandins_2023_106726 crossref_primary_10_1152_ajplung_00423_2004 crossref_primary_10_1016_j_ejim_2012_02_010 crossref_primary_10_1016_0090_1229_91_90130_3 crossref_primary_10_1016_j_arr_2021_101359 crossref_primary_10_4049_jimmunol_181_8_5637 crossref_primary_10_1111_j_1365_2222_1996_tb00639_x crossref_primary_10_1007_s002040050052 crossref_primary_10_1054_plef_2002_0436 crossref_primary_10_1096_fj_03_0053rev crossref_primary_10_1016_0006_2952_94_90220_8 crossref_primary_10_1046_j_1525_1381_1999_t01_1_99231_x crossref_primary_10_1016_0167_4889_93_90104_W crossref_primary_10_1111_j_1472_9725_2004_00040_x crossref_primary_10_1002_j_1875_9114_1997_tb03698_x crossref_primary_10_1074_jbc_M100429200 crossref_primary_10_1021_cr200246d crossref_primary_10_1016_0003_9861_91_90239_F crossref_primary_10_1016_j_iac_2005_09_004 crossref_primary_10_1016_S0952_3278_97_90523_8 crossref_primary_10_1074_jbc_273_49_32842 crossref_primary_10_1007_s00109_017_1542_4 crossref_primary_10_1002_j_1552_4604_1998_tb04463_x crossref_primary_10_18632_oncotarget_25482 crossref_primary_10_1038_onc_2014_85 crossref_primary_10_1084_jem_185_6_1123 crossref_primary_10_1091_mbc_e12_06_0489 crossref_primary_10_1016_j_bbagen_2007_03_002 crossref_primary_10_1074_jbc_274_33_23341 crossref_primary_10_1007_BF03401647 crossref_primary_10_1021_acs_jcim_9b00941 crossref_primary_10_1016_j_biomaterials_2014_02_029 crossref_primary_10_1006_bbrc_2001_4847 crossref_primary_10_3892_ijo_2014_2344 crossref_primary_10_1021_jm501185j crossref_primary_10_1016_0024_3205_94_00872_8 crossref_primary_10_1517_13543776_13_1_1 crossref_primary_10_1016_0928_0987_94_90106_6 crossref_primary_10_5847_wjem_j_issn_1920_8642_2012_02_005 crossref_primary_10_1016_S0005_2760_97_00076_3 crossref_primary_10_1517_13543776_2013_791678 crossref_primary_10_1007_s11033_010_0610_4 crossref_primary_10_1074_jbc_M110_205567 crossref_primary_10_1016_j_bbalip_2006_02_018 crossref_primary_10_1016_j_bbalip_2012_07_011 crossref_primary_10_1038_s41598_017_09795_w crossref_primary_10_1016_j_ejphar_2010_05_003 crossref_primary_10_1164_ajrccm_147_4_839 crossref_primary_10_1074_jbc_271_36_22203 crossref_primary_10_1016_0005_2760_94_00185_2 crossref_primary_10_1111_j_1398_9995_2005_00780_x crossref_primary_10_1111_j_1749_6632_1994_tb52742_x crossref_primary_10_1016_j_bbamcr_2007_07_008 crossref_primary_10_1016_S0954_6111_98_90380_8 crossref_primary_10_1111_j_1749_6632_1999_tb07994_x crossref_primary_10_2139_ssrn_4126767 crossref_primary_10_1016_S0021_9258_19_67757_4 crossref_primary_10_3109_00207454_2014_967769 crossref_primary_10_1111_j_1432_1033_1993_tb18012_x crossref_primary_10_4049_jimmunol_172_1_231 crossref_primary_10_1053_spid_2001_19233 crossref_primary_10_1016_j_pep_2008_01_010 crossref_primary_10_1056_NEJM199901213400306 crossref_primary_10_1371_journal_pone_0068859 crossref_primary_10_1016_0005_2760_92_90252_Q crossref_primary_10_1016_S0021_9258_19_51063_8 crossref_primary_10_1016_0005_2760_92_90297_9 crossref_primary_10_1016_S0091_6749_95_70151_6 crossref_primary_10_1016_j_bbrc_2023_05_066 crossref_primary_10_1016_S0021_9258_18_48532_8 crossref_primary_10_1016_j_plefa_2003_04_005 crossref_primary_10_1016_j_plefa_2011_04_022 crossref_primary_10_1016_S1050_4648_95_80041_7 crossref_primary_10_1097_MCO_0b013e32835017cc crossref_primary_10_1081_JAS_120017985 crossref_primary_10_1074_jbc_M211102200 crossref_primary_10_1159_000353694 crossref_primary_10_1046_j_1365_2222_2003_01733_x crossref_primary_10_1016_0005_2760_94_90057_4 crossref_primary_10_1126_scitranslmed_abi8633 crossref_primary_10_1182_blood_V91_1_64_64_64_74 crossref_primary_10_1016_j_pharmthera_2006_05_009 crossref_primary_10_1016_j_bcp_2016_09_021 crossref_primary_10_1111_j_1432_1033_1997_00587_x crossref_primary_10_1074_jbc_271_19_11356 crossref_primary_10_1253_circj_69_1029 crossref_primary_10_1080_13543776_2017_1276568 crossref_primary_10_1016_j_bbalip_2008_04_005 crossref_primary_10_1093_hmg_ddv132 crossref_primary_10_1124_mol_62_2_200 crossref_primary_10_4199_C00052ED1V01Y201204GMM001 crossref_primary_10_1164_ajrccm_164_11_2008137 crossref_primary_10_1159_000481204 crossref_primary_10_1186_s12903_023_02712_w crossref_primary_10_1007_BF03259270 crossref_primary_10_1371_journal_pone_0132607 crossref_primary_10_1177_014107689709000405 crossref_primary_10_1046_j_1432_1327_1999_00818_x crossref_primary_10_1074_jbc_RA119_012069 crossref_primary_10_1080_09687680802446534 crossref_primary_10_1182_blood_2005_01_0241 crossref_primary_10_1038_ni971 crossref_primary_10_1124_jpet_109_158089 crossref_primary_10_1007_BF01976753 crossref_primary_10_1016_j_ejphar_2005_12_070 crossref_primary_10_1152_ajpheart_00003_2001 crossref_primary_10_1074_jbc_272_36_22934 crossref_primary_10_1136_thx_50_9_1005 crossref_primary_10_1007_BF02737596 crossref_primary_10_1038_nrd_2015_4 crossref_primary_10_1096_fj_02_1157fje crossref_primary_10_1046_j_1365_3164_2001_00213_x crossref_primary_10_1016_0952_3278_92_90192_L crossref_primary_10_1016_S0021_9258_18_53251_8 crossref_primary_10_1038_sj_bjp_0707416 crossref_primary_10_4049_jimmunol_1601569 crossref_primary_10_1016_0167_4889_93_90012_E crossref_primary_10_1016_0952_3278_92_90081_S crossref_primary_10_1371_journal_pone_0041063 crossref_primary_10_1517_14656566_1_5_1021 crossref_primary_10_1073_pnas_0905364106 crossref_primary_10_1111_1755_5922_12328 crossref_primary_10_3390_molecules24142530 crossref_primary_10_1067_mhn_2000_105996 crossref_primary_10_1074_jbc_270_39_22653 crossref_primary_10_1084_jem_185_6_1065 crossref_primary_10_1111_j_1476_5381_2011_01649_9_x crossref_primary_10_1016_0952_3278_92_90225_8 crossref_primary_10_1097_00004872_200202000_00016 crossref_primary_10_1126_science_1197203 crossref_primary_10_1074_jbc_270_7_3239 crossref_primary_10_1074_jbc_M003505200 crossref_primary_10_1016_j_micinf_2010_03_016 crossref_primary_10_1002_humu_20666 crossref_primary_10_1016_0006_2952_93_90382_7 crossref_primary_10_1161_CIRCRESAHA_121_319687 crossref_primary_10_1016_0092_8674_95_90005_5 crossref_primary_10_1172_JCI0214869 crossref_primary_10_1371_journal_pone_0106596 crossref_primary_10_1096_fj_12_205286 crossref_primary_10_1111_j_1432_1033_1995_tb20778_x crossref_primary_10_4049_jimmunol_173_3_1503 crossref_primary_10_1016_0165_6147_92_90100_K crossref_primary_10_1016_S1388_1981_00_00115_3 crossref_primary_10_1016_j_bbrc_2009_04_007 crossref_primary_10_1002_eji_200323446 crossref_primary_10_1016_j_bcp_2016_08_023 crossref_primary_10_1016_0090_6980_92_90024_N crossref_primary_10_1111_j_1432_1033_1994_tb19940_x crossref_primary_10_1006_phrs_2001_0872 crossref_primary_10_1211_0022357021080 crossref_primary_10_1016_0145_2126_94_90053_1 crossref_primary_10_1016_S0306_3623_96_00419_3 crossref_primary_10_1016_j_smim_2017_07_010 crossref_primary_10_1007_s10517_018_4210_y crossref_primary_10_1016_0016_5085_92_90760_V crossref_primary_10_1021_jm900945d crossref_primary_10_1006_abbi_2000_2168 crossref_primary_10_1016_S0889_857X_21_00465_8 crossref_primary_10_1016_j_jep_2015_04_022 crossref_primary_10_1016_j_jpsychires_2012_12_011 crossref_primary_10_1016_S0033_8389_22_00245_7 crossref_primary_10_1016_S0304_3835_97_00176_6 crossref_primary_10_1016_0090_6980_91_90114_U crossref_primary_10_1016_j_atherosclerosis_2008_07_025 crossref_primary_10_1016_j_phrs_2020_104857 crossref_primary_10_1111_j_1432_1033_1995_513_b_x crossref_primary_10_1164_ajrccm_143_5_Pt_2_S86 crossref_primary_10_1038_ki_1992_13 crossref_primary_10_1186_1749_8090_6_81 crossref_primary_10_1016_0922_4106_94_90151_1 crossref_primary_10_1016_j_ejphar_2009_02_023 crossref_primary_10_1038_sj_bjp_0704189 crossref_primary_10_1155_2019_2749173 crossref_primary_10_1016_S0891_5849_97_00270_0 crossref_primary_10_1371_journal_pgen_1002454 crossref_primary_10_1067_mai_2003_60 crossref_primary_10_1042_BJ20070289 crossref_primary_10_1111_j_1365_2141_1995_tb05588_x crossref_primary_10_1110_ps_8_3_689 crossref_primary_10_1080_01902140490476391 crossref_primary_10_1038_ki_1991_55 crossref_primary_10_1046_j_1365_2222_1998_028s5164_x crossref_primary_10_3389_fmicb_2021_739385 crossref_primary_10_1074_jbc_274_40_28264 crossref_primary_10_1097_01_hjh_0000198027_76729_b8 crossref_primary_10_1016_j_pharmthera_2006_03_008 crossref_primary_10_1007_BF00666096 crossref_primary_10_3390_ijms25073961 crossref_primary_10_1007_BF00666095 crossref_primary_10_1038_s41589_020_0544_7 crossref_primary_10_1002_jez_1402690403 crossref_primary_10_1038_sj_ijo_0803147 crossref_primary_10_1016_S0960_894X_00_80520_X crossref_primary_10_1152_ajpregu_1999_276_1_R52 crossref_primary_10_1016_S0021_9258_18_41633_X crossref_primary_10_1016_S0300_9572_00_00168_4 crossref_primary_10_1562_0031_8655_2003_078_0068_IOTNFB_2_0_CO_2 crossref_primary_10_1111_j_1365_2559_2012_04258_x crossref_primary_10_1016_0169_328X_95_00108_5 crossref_primary_10_1016_S0335_7457_98_80138_X crossref_primary_10_1189_jlb_0406240 crossref_primary_10_1016_S0014_2999_98_00563_9 crossref_primary_10_1016_j_bbagen_2012_09_018 crossref_primary_10_1177_039463200501800303 crossref_primary_10_1093_cvr_cvt247 crossref_primary_10_1111_j_1440_1681_2004_03996_x crossref_primary_10_1002_wnan_1374 crossref_primary_10_1007_s00439_009_0654_5 crossref_primary_10_1007_s00439_008_0489_5 crossref_primary_10_1194_jlr_M017822 crossref_primary_10_1016_S0192_0561_00_00010_2 crossref_primary_10_1046_j_0306_5251_2001_01509_x crossref_primary_10_1016_S0167_4781_99_00112_8 crossref_primary_10_1016_0952_3278_95_90063_2 crossref_primary_10_1096_fj_07_103457 crossref_primary_10_1074_jbc_270_30_17993 crossref_primary_10_1046_j_1472_9725_2001_t01_1_00007_x crossref_primary_10_1074_jbc_M116_725325 crossref_primary_10_1016_j_cellsig_2007_08_011 crossref_primary_10_1016_j_plipres_2007_12_003 crossref_primary_10_1021_cr100392s crossref_primary_10_1007_BF01307189 crossref_primary_10_1074_jbc_M311404200 crossref_primary_10_1074_jbc_M506513200 crossref_primary_10_1111_j_1749_6632_1991_tb37968_x crossref_primary_10_2170_jjphysiol_54_71 crossref_primary_10_1074_jbc_273_47_31237 crossref_primary_10_1016_S0021_9258_18_54346_5 crossref_primary_10_1074_jbc_M003504200 crossref_primary_10_1016_0090_6980_94_90031_0 crossref_primary_10_1111_j_1398_9995_2006_00980_x crossref_primary_10_1074_jbc_M203074200 crossref_primary_10_1111_j_1432_1033_1996_0090r_x crossref_primary_10_1016_0016_5085_95_90296_1 crossref_primary_10_1086_428066 crossref_primary_10_1155_2022_8456968 crossref_primary_10_1016_S0889_8561_05_70272_1 crossref_primary_10_1016_S1388_1981_02_00286_X crossref_primary_10_1021_acs_biochem_5b00930 crossref_primary_10_1021_acs_jmedchem_1c00806 crossref_primary_10_1007_s11888_012_0146_1 crossref_primary_10_1172_JCI200318338 crossref_primary_10_1016_j_jbc_2022_102282 crossref_primary_10_1111_j_1432_1033_1992_tb16685_x crossref_primary_10_1038_ng1311 crossref_primary_10_1016_j_bmcl_2009_10_131 crossref_primary_10_1021_bi401621d crossref_primary_10_1111_j_1600_065X_2007_00512_x crossref_primary_10_1016_S0952_3278_03_00071_1 crossref_primary_10_1111_j_1749_6632_1994_tb52725_x crossref_primary_10_1016_0145_2126_93_90007_8 crossref_primary_10_1042_BJ20060669 crossref_primary_10_1074_jbc_M705822200 crossref_primary_10_1016_S0090_6980_02_00032_1 crossref_primary_10_1517_13543784_4_3_243 crossref_primary_10_1084_jem_20091240 crossref_primary_10_1016_0165_6147_91_90500_R crossref_primary_10_1016_S0090_6980_00_00095_2 crossref_primary_10_1038_nsb1297_1003 crossref_primary_10_1021_jm801085s crossref_primary_10_1073_pnas_0808211106 crossref_primary_10_1016_j_jacc_2005_06_075 crossref_primary_10_4049_jimmunol_165_8_4640 crossref_primary_10_1111_j_1476_5381_1992_tb14491_x crossref_primary_10_1016_S0022_2275_20_41320_3 crossref_primary_10_1016_j_arcmed_2010_11_001 crossref_primary_10_1016_S0021_9258_18_99187_8 crossref_primary_10_1073_pnas_141221498 crossref_primary_10_1016_0952_3278_95_90027_6 crossref_primary_10_1016_S0335_7457_05_80050_4 crossref_primary_10_1074_jbc_271_11_6179 crossref_primary_10_1016_0014_5793_93_80528_3 crossref_primary_10_1016_0090_6980_95_00003_S crossref_primary_10_1016_0952_3278_95_90004_7 crossref_primary_10_1111_j_1432_1033_1991_tb15936_x crossref_primary_10_1111_j_1742_1241_1995_tb09971_x crossref_primary_10_1369_0022155414545334 crossref_primary_10_1111_j_1749_6632_1994_tb52726_x crossref_primary_10_1124_jpet_103_055145 crossref_primary_10_1124_mol_53_2_313 crossref_primary_10_1006_phrs_2000_0784 crossref_primary_10_1074_jbc_M110_150177 crossref_primary_10_1189_jlb_0604338 crossref_primary_10_1016_j_plefa_2005_10_005 crossref_primary_10_1007_BF01991022 crossref_primary_10_1096_fj_15_278010 crossref_primary_10_1007_s12013_013_9579_7 crossref_primary_10_1016_S0014_5793_99_00397_X crossref_primary_10_1158_1078_0432_CCR_18_3549 crossref_primary_10_3390_biomedicines11041216 crossref_primary_10_1152_ajplung_00181_2006 crossref_primary_10_1016_S0889_8553_05_70249_1 crossref_primary_10_1038_nrd1796 crossref_primary_10_1016_j_bbagen_2014_05_016 crossref_primary_10_1016_j_biotechadv_2018_02_010 crossref_primary_10_1016_0952_3278_93_90099_I crossref_primary_10_1016_S0378_8741_97_01520_1 crossref_primary_10_1016_j_jns_2013_10_013 crossref_primary_10_1038_nmeth_f_250 crossref_primary_10_1002_ardp_19943270103 crossref_primary_10_1006_pupt_2000_0262 crossref_primary_10_1016_0028_3908_96_00131_1 crossref_primary_10_1006_bbrc_1998_8789 crossref_primary_10_1002_jcb_20880 crossref_primary_10_1158_1078_0432_CCR_04_0945 crossref_primary_10_1124_mol_62_2_250 crossref_primary_10_1016_j_plefa_2008_09_024 crossref_primary_10_1007_s40199_019_00319_7 crossref_primary_10_1016_0928_0987_94_90231_3 crossref_primary_10_1046_j_1365_2222_2001_01121_x crossref_primary_10_1016_S0021_9258_18_53486_4 crossref_primary_10_1016_S0306_4522_02_00411_6 crossref_primary_10_1111_j_1476_5381_1994_tb13067_x crossref_primary_10_1007_s12035_018_1055_3 crossref_primary_10_1172_JCI92885 crossref_primary_10_2165_00003495_200161020_00012 crossref_primary_10_1038_ki_1997_209 crossref_primary_10_1016_j_bbalip_2015_08_010 crossref_primary_10_1074_jbc_273_16_9886 crossref_primary_10_1016_S0952_3278_03_00081_4 crossref_primary_10_1016_0950_3528_94_90009_4 crossref_primary_10_1111_j_1432_1033_1993_tb18399_x crossref_primary_10_1016_S0952_3278_03_00070_X crossref_primary_10_1096_fj_04_2258fje crossref_primary_10_1016_S1081_1206_10_63106_7 crossref_primary_10_1016_j_phymed_2005_01_012 crossref_primary_10_1111_j_1432_1033_1996_0250q_x crossref_primary_10_1016_j_bbalip_2018_09_011 crossref_primary_10_1164_ajrccm_157_6_mar4 crossref_primary_10_1016_j_cellsig_2011_07_002 crossref_primary_10_1016_0005_2760_96_00077_X crossref_primary_10_1016_0090_6980_93_90091_K crossref_primary_10_1111_odi_12544 crossref_primary_10_1002_jcp_10285 crossref_primary_10_1096_fasebj_12_6_439 crossref_primary_10_1080_17435390_2023_2204161 crossref_primary_10_1164_ajrccm_158_supplement_2_13tac180 crossref_primary_10_1016_S0960_894X_00_00076_7 crossref_primary_10_1124_mol_66_2_220 crossref_primary_10_1111_j_1432_1033_1992_tb17341_x crossref_primary_10_1016_S0014_2999_02_01933_7 crossref_primary_10_1186_1471_2202_13_146 crossref_primary_10_1074_jbc_274_44_31476 crossref_primary_10_1016_S0002_9440_10_64198_3 crossref_primary_10_1111_j_1432_1033_1996_0572u_x crossref_primary_10_1016_0016_5085_95_90752_1 crossref_primary_10_1038_sj_bjp_0701611 crossref_primary_10_1074_jbc_272_46_29068 crossref_primary_10_1016_j_ejmech_2017_07_019 crossref_primary_10_1016_0098_2997_91_90013_C crossref_primary_10_1016_j_bcp_2005_04_018 crossref_primary_10_1586_14737159_8_4_495 crossref_primary_10_1016_0197_0186_91_90161_6 crossref_primary_10_1002_hep_29633 crossref_primary_10_1111_j_1365_2222_2007_02733_x crossref_primary_10_1111_j_1365_2125_1995_tb04535_x crossref_primary_10_1186_1742_2094_9_127 crossref_primary_10_3389_fphar_2022_838782 crossref_primary_10_1038_sj_bjp_0703626 crossref_primary_10_1111_bph_14859 crossref_primary_10_1016_0031_6865_94_90024_8 crossref_primary_10_1093_jn_132_12_3740 crossref_primary_10_1111_j_1398_9995_2010_02514_x crossref_primary_10_1016_0169_4758_95_80185_5 crossref_primary_10_1074_jbc_271_14_7965 crossref_primary_10_1002_art_20632 crossref_primary_10_1016_j_abb_2011_09_004 crossref_primary_10_1016_S1388_1981_99_00149_3 crossref_primary_10_1016_j_jpba_2008_09_034 crossref_primary_10_1158_1940_6207_CAPR_08_0001 crossref_primary_10_1016_S1081_1206_10_63465_5 crossref_primary_10_1016_S0014_2999_00_00405_2 crossref_primary_10_1007_BF02005767 crossref_primary_10_1016_0304_3835_95_03923_K crossref_primary_10_1046_j_1365_2222_1996_d01_403_x crossref_primary_10_1007_s12035_023_03417_5 crossref_primary_10_1006_geno_1998_5651 crossref_primary_10_1016_0092_8674_93_80057_L crossref_primary_10_1021_acs_jmedchem_9b00555 crossref_primary_10_1111_bph_12451 crossref_primary_10_1016_S0022_2275_20_35344_X crossref_primary_10_1016_S1388_1981_00_00089_5 crossref_primary_10_3109_03602532_2011_567391 crossref_primary_10_1562_0031_8655_2003_0780068IOTNFB2_0_CO2 crossref_primary_10_1111_j_1432_1033_1995_tb20671_x crossref_primary_10_3858_emm_2011_43_2_012 crossref_primary_10_1016_S0891_5849_00_00230_6 crossref_primary_10_1016_S0021_9258_18_93004_8 crossref_primary_10_1074_jbc_274_42_29812 crossref_primary_10_1517_13543776_3_1_50 crossref_primary_10_1016_0006_2952_92_90128_6 crossref_primary_10_1016_j_biocel_2013_05_009 crossref_primary_10_1038_tp_2013_106 crossref_primary_10_1074_jbc_M003191200 crossref_primary_10_1152_ajpcell_1997_273_6_C2057 crossref_primary_10_1159_000445680 crossref_primary_10_1016_S1016_8478_23_07389_2 crossref_primary_10_7124_bc_0008DC crossref_primary_10_1074_jbc_272_15_10182 crossref_primary_10_1016_S0014_2999_98_00262_3 crossref_primary_10_1016_0192_0561_94_00093_4 crossref_primary_10_1074_jbc_274_36_25594 crossref_primary_10_1016_S1388_1981_03_00092_1 crossref_primary_10_1517_13543776_2_7_987 crossref_primary_10_1016_S0021_9258_17_45446_9 crossref_primary_10_1016_0024_3205_96_00426_2 crossref_primary_10_1073_pnas_0308523101 crossref_primary_10_1146_annurev_arplant_48_1_355 crossref_primary_10_1111_j_1365_2222_2005_02188_x crossref_primary_10_1038_s41392_020_00443_w crossref_primary_10_1165_ajrcmb_23_3_f197 crossref_primary_10_3109_01902149809087390 crossref_primary_10_4049_jimmunol_173_1_624 crossref_primary_10_1016_S0952_3278_98_90100_4 crossref_primary_10_1016_j_bmcl_2010_06_011 crossref_primary_10_1161_01_ATV_0000252680_72734_10 crossref_primary_10_1016_S0223_5234_03_00115_6 crossref_primary_10_1254_fpj_124_415 crossref_primary_10_1254_jjp_65_297 crossref_primary_10_1172_JCI13241 crossref_primary_10_1016_S0960_894X_01_81016_7 crossref_primary_10_1016_j_bbrc_2009_02_074 crossref_primary_10_1111_j_1432_1033_1994_tb18867_x crossref_primary_10_1186_1477_5956_5_12 crossref_primary_10_1002__SICI_1097_4652_199703_170_3_309__AID_JCP12_3_0_CO_2_9 crossref_primary_10_3390_ijms21103595 crossref_primary_10_1080_17471060701682245 crossref_primary_10_1371_journal_pone_0098532 crossref_primary_10_1038_sj_ejhg_5201854 crossref_primary_10_1007_s12019_996_0010_9 crossref_primary_10_1016_S0005_2760_98_00054_X crossref_primary_10_1126_scisignal_abb0969 crossref_primary_10_1016_S0378_4347_99_00099_7 crossref_primary_10_1096_fj_02_0224fje crossref_primary_10_1002_med_21251 crossref_primary_10_1084_jem_20020044 crossref_primary_10_1126_science_1144346 crossref_primary_10_1016_0006_2952_94_90264_X crossref_primary_10_1016_S0960_894X_99_00399_6 crossref_primary_10_4049_jimmunol_1302187 crossref_primary_10_1016_j_ab_2005_12_025 crossref_primary_10_1016_j_molmed_2005_03_001 crossref_primary_10_1096_fj_201500210R crossref_primary_10_1164_ajrccm_161_supplement_1_ltta_3 crossref_primary_10_1111_j_1600_0609_2007_00967_x crossref_primary_10_1164_ajrccm_161_supplement_1_ltta_5 crossref_primary_10_1189_jlb_0811402 crossref_primary_10_1111_j_1745_4522_2009_01150_x crossref_primary_10_1126_sciimmunol_abf6734 crossref_primary_10_1016_S0022_2275_20_32448_2 crossref_primary_10_1046_j_1365_2796_1999_00418_x crossref_primary_10_1111_1523_1747_ep12329890 crossref_primary_10_1194_jlr_P022814 crossref_primary_10_1039_c4pp00304g crossref_primary_10_1007_BF01996094 crossref_primary_10_1016_S1094_5539_03_00070_1 crossref_primary_10_18093_0869_0189_2008_0_1_101_107 crossref_primary_10_4049_jimmunol_163_1_456 crossref_primary_10_1111_j_1476_5381_1993_tb12864_x crossref_primary_10_1182_blood_V91_1_64 crossref_primary_10_1038_ki_1994_401 |
| Cites_doi | 10.1073/pnas.80.14.4349 10.1073/pnas.85.2.416 10.1016/0304-4165(85)90160-6 10.1016/S0021-9258(18)38066-9 10.1016/0022-2836(82)90515-0 10.1038/321075a0 10.1038/326073a0 10.1038/343278a0 10.1073/pnas.69.6.1408 10.1038/301621a0 10.1016/0003-2697(86)90403-3 10.1016/S0021-9258(19)81487-4 10.1016/0022-2836(84)90309-7 10.1073/pnas.78.6.3824 10.1021/bi00591a005 10.1139/y89-073 10.1126/science.6301011 10.1126/science.2820055 |
| ContentType | Journal Article |
| Copyright | 1991 INIST-CNRS Copyright Macmillan Journals Ltd. Jan 18, 1990 Copyright Nature Publishing Group Jan 18, 1990 |
| Copyright_xml | – notice: 1991 INIST-CNRS – notice: Copyright Macmillan Journals Ltd. Jan 18, 1990 – notice: Copyright Nature Publishing Group Jan 18, 1990 |
| DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7QG 7QL 7QP 7QR 7RV 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7X2 7X7 7XB 88A 88E 88G 88I 8AF 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK 8G5 ABJCF ABUWG AFKRA ARAPS ATCPS AZQEC BBNVY BEC BENPR BGLVJ BHPHI BKSAR C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M2M M2O M2P M7N M7P M7S MBDVC NAPCQ P5Z P62 P64 PATMY PCBAR PDBOC PQEST PQQKQ PQUKI PSYQQ PTHSS PYCSY Q9U R05 RC3 S0X SOI 7T3 M81 7SC 7SP 7SR 7TB 7U5 8BQ F28 JG9 JQ2 KR7 L7M L~C L~D 7X8 |
| DOI | 10.1038/343282a0 |
| DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts ProQuest Nursing and Allied Health Journals Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Meteorological & Geoastrophysical Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection (Proquest) ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database ProQuest Pharma Collection ProQuest Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest Central UK/Ireland Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection eLibrary ProQuest Central Technology Collection ProQuest Natural Science Collection Earth, Atmospheric & Aquatic Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep AIDS and Cancer Research Abstracts SciTech Premium Collection (Proquest) (PQ_SDU_P3) ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agriculture Science Database Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Psychology Journals (ProQuest) ProQuest Research Library ProQuest Science Journals Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Research Library (Corporate) Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Earth, Atmospheric & Aquatic Science Database Materials Science Collection ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest One Psychology Engineering Collection Environmental Science Collection ProQuest Central Basic University of Michigan Genetics Abstracts SIRS Editorial Environment Abstracts Human Genome Abstracts Biochemistry Abstracts 3 Computer and Information Systems Abstracts Electronics & Communications Abstracts Engineered Materials Abstracts Mechanical & Transportation Engineering Abstracts Solid State and Superconductivity Abstracts METADEX ANTE: Abstracts in New Technology & Engineering Materials Research Database ProQuest Computer Science Collection Civil Engineering Abstracts Advanced Technologies Database with Aerospace Computer and Information Systems Abstracts Academic Computer and Information Systems Abstracts Professional MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Agricultural Science Database ProQuest One Psychology Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts elibrary ProQuest AP Science SciTech Premium Collection Environmental Sciences and Pollution Management Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Biological Science Collection Chemoreception Abstracts ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Meteorological & Geoastrophysical Abstracts - Academic University of Michigan Technology Collection Technology Research Database SIRS Editorial Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Earth, Atmospheric & Aquatic Science Collection Genetics Abstracts ProQuest Engineering Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Research Library ProQuest Materials Science Collection ProQuest Public Health ProQuest Central Basic ProQuest Science Journals ProQuest Nursing & Allied Health Source ProQuest Psychology Journals (Alumni) ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library ProQuest Psychology Journals Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) Human Genome Abstracts Biochemistry Abstracts 3 Materials Research Database Civil Engineering Abstracts Computer and Information Systems Abstracts – Academic Mechanical & Transportation Engineering Abstracts Electronics & Communications Abstracts ProQuest Computer Science Collection Computer and Information Systems Abstracts METADEX Computer and Information Systems Abstracts Professional Engineered Materials Abstracts Solid State and Superconductivity Abstracts Advanced Technologies Database with Aerospace ANTE: Abstracts in New Technology & Engineering MEDLINE - Academic |
| DatabaseTitleList | Agricultural Science Database Human Genome Abstracts Materials Research Database MEDLINE Agricultural Science Database MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Physics |
| EISSN | 1476-4687 |
| EndPage | 284 |
| ExternalDocumentID | 1725172 10_1038_343282a0 2300173 19478659 343282a0 |
| Genre | Journal Article Comparative Study |
| GeographicLocations | New York United States--US |
| GeographicLocations_xml | – name: New York – name: United States--US |
| GroupedDBID | - 02 08R 0R 0WA 123 186 29M 2KS 3EH 3O- 3V. 4 4.4 42X 53G 55 5RE 69O 6XO 7RV 7X2 7X7 7XC 85S 88A 88E 88I 8AF 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ 8G5 8R4 8R5 8WZ 9M8 A6W A7Z A8Z AADWK AAEEF AAIKC AAJWC AAPBV AAVBQ AAYJO AAYOK AAZLF ABAWZ ABDBF ABDEX ABEFU ABFLS ABGIJ ABIVO ABJCF ABOCM ABPPZ ABPTK ABUWG ABWJO ACBTR ACGFS ACGOD ACIWK ACNCT ACPRK ACTDY ADBBV ADBIT AEFTE AENEX AETEA AFDAS AFFDN AFFNX AFKRA AFLOW AFMIJ AFRAH AGEZK AGHTU AGNAY AGSOS AHGBK AHMBA AIDAL AIDUJ ALFFA ALMA_UNASSIGNED_HOLDINGS ARAPS ASPBG ATCPS AVRDS AVWKF AXYYD AZFZN AZQEC B-7 BBAFP BBNVY BCU BEC BENPR BGLVJ BHPHI BIN BKEYQ BKKNO BKSAR BPHCQ BVXVI CJ0 CS3 D1I D1J D1K DB5 DU5 DWQXO DZ E.- E.L EAP EBS EE. EJD EMH ESE ET EXGXG F20 F5P FA8 FQGFK FSGXE FYUFA G8K GJ GNUQQ GUQSH HCIFZ HG6 HR HZ I-U IH2 J5H K6- K78 KB. KM KOO L-9 L6V L7B LK5 LK8 M0K M0L M1P M2M M2O M2P M7P M7R M7S MVM N9A NAPCQ NEJ NEPJS O9- OHM OHT OMK P-O P2P P62 PATMY PCBAR PDBOC PQEST PQQKQ PQUKI PROAC PSQYO PTHSS PYCSY Q2X R05 RIG RND RNS RNT RNTTT RXW S0X SC5 SIXXV SJFOW SJN SKT SNYQT TAE TN5 TSG TWZ U1R U5U UBY UHB UKR UQL VOH VQA WH7 X X7M XFK XHC XKW XZL Y6R YNT YQJ YXB YZZ Z ZA5 ZCG ZGI ZHY ZKB ZR0 ZY4 --- --Z -DZ -ET -~X .-4 .55 .CO .GJ .HR .XZ 00M 07C 08P 0B8 0R~ 1CY 1OL 1VR 1VW 2XV 354 39C 41X 41~ 4R4 663 68V 6TJ 70F 79B 97F 97L AADEA AAEXX AAGJQ AAHTB AAJMP AAJYS AAKAB AAKAS AAMNW AASDW AAUGY AAYEP ABEEJ ABFSI ABGFU ABLJU ABPEJ ABTAH ABVXF ABZEH ACBEA ACBMV ACBNA ACBRV ACBYP ACGFO ACIGE ACKOT ACTTH ACVWB ACWUS ADFPY ADFRT ADMDM ADQMX ADRHT ADYSU ADZCM ADZGE AEDAW AFHKK AFNRJ AFSHS AGAYW AGCDD AGGBP AGHSJ AHSBF AIYXT AJDOV AJUXI AMRJV AMTXH APEBS ARMCB ARTTT ATWCN B0M BCR BDKGC BES BKOMP BLC CCPQU DO4 EAD EAS EAZ EBC EBD EBO ECC EMB EMF EMK EMOBN EPL EPS ESN ESTFP ESX EX3 FAC FEDTE HZ~ I-F IAO ICQ IEA IEP IGS IHR INH INR IOF IPY IQODW ISR ITC LSO N4W OBC OES OHH OVD PEA PM3 PSYQQ PV9 QS- R4F RHI SHXYY SV3 TAOOD TBHMF TDRGL TEORI TH9 TUD TUS UAO UKHRP UMD USG VVN WOW X7L XIH XOL YAE YCJ YFH YJ6 YOC YQI YQT YR2 YV5 YXA YYP YYQ ZCA ZE2 ZKG ~02 ~7V ~88 ~8M ~G0 ~KM AAHBH AAYZH ABJNI ACMJI ADUKH AFRQD ALIPV CGR CUY CVF ECM EIF HMCUK NPM AAYXX ACBWK AFBBN CITATION HVGLF LGEZI LOTEE NADUK NXXTH ODYON UIG 7QG 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7XB 8FD 8FK C1K FR3 H94 K9. KL. M7N MBDVC P64 Q9U RC3 SOI 7T3 ABDPE M81 7SC 7SP 7SR 7TB 7U5 8BQ F28 JG9 JQ2 KR7 L7M L~C L~D 7X8 |
| ID | FETCH-LOGICAL-c449t-f89976178ef8df0729b5bc52e005e002e8747c7d98d3af29f9b1ad38861fd29e3 |
| IEDL.DBID | 8FG |
| ISSN | 0028-0836 |
| IngestDate | Fri Oct 25 06:29:35 EDT 2024 Fri Oct 25 21:43:11 EDT 2024 Sat Oct 26 00:42:23 EDT 2024 Thu Oct 10 21:00:05 EDT 2024 Thu Oct 10 21:06:41 EDT 2024 Thu Sep 26 17:07:28 EDT 2024 Tue Oct 15 23:14:27 EDT 2024 Sun Oct 29 17:08:56 EDT 2023 Thu Oct 07 19:35:00 EDT 2021 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6255 |
| Keywords | Human Rat Nucleotide sequence Enzyme Arachidonic acid derivatives Rodentia Biosynthesis Inflammation Gene expression Leukotriene Binding protein Vertebrata Mammalia Cell line Complementary DNA Lipoxygenase Aminoacid sequence |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c449t-f89976178ef8df0729b5bc52e005e002e8747c7d98d3af29f9b1ad38861fd29e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
| PMID | 2300173 |
| PQID | 204449801 |
| PQPubID | 40569 |
| PageCount | 3 |
| ParticipantIDs | proquest_miscellaneous_79605451 proquest_miscellaneous_743423988 proquest_miscellaneous_15445807 proquest_journals_2229181858 proquest_journals_204449801 crossref_primary_10_1038_343282a0 pubmed_primary_2300173 pascalfrancis_primary_19478659 nature_primary_343282a0 |
| ProviderPackageCode | RNTTT ABGIJ AAZLF DB5 L-9 RND RNT AADWK AAYJO AHGBK EE. |
| PublicationCentury | 1900 |
| PublicationDate | 1990-01-18 |
| PublicationDateYYYYMMDD | 1990-01-18 |
| PublicationDate_xml | – month: 01 year: 1990 text: 1990-01-18 day: 18 |
| PublicationDecade | 1990 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Nature (London) |
| PublicationTitleAlternate | Nature |
| PublicationYear | 1990 |
| Publisher | Nature Publishing Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing – name: Nature Publishing Group |
| References | Jaken, S., Leach, K. L. (b14) 1988; 23 Rouzer, C. A. (b8) 1988; 263 Kraft, A. S., Anderson, W. B. (b13) 1983; 301 Dixon, R. A. F. (b18) 1986; 321 Gillard, J. W. (b3) 1989; 67 Guindon, Y., Fortin, R., Lau, C. K., Rokach, J., Yoakim, C. (b10) 1984 Rouzer, C. A., Kargman, S. (b11) 1988; 263 Rouzer, C. A. (b12) Ham, E. A. (b21) 1983; 80 Miller, D. K. (b4) 1990; 343 Chargwin, J. M., Przybyla, A. E., MacDonald, R. J., Rutter, W. J. (b16) 1979; 18 Hattori, M., Sakaki, Y. (b20) 1983; 152 Evans, J. F., Dupuis, P., Ford-Hutchinson, A. W. (b9) 1985; 840 Dixon (b22) 1987; 326 Eisenberg, D., Schwarz, E., Kamaromy, M., Wall, R. (b7) 1982; 179 Aviv, H., Leder, P. (b17) 1972; 69 Dixon, R. A. F. (b15) 1988; 85 Maniatis, T., Fritsch, E. F., Sambrook, J. (b19) 1982 Kyte, J., Doolittle, R. F. (b6) 1982; 157 Samuelsson, B., Dahlen, S. E., Lindgren, J. A., Rouzer, C. A., Serhan, C. N. (b2) 1987; 237 Hopp, T. P., Woods, K. R. (b5) 1981; 78 Samuelsson, B. (b1) 1983; 220 BF343282a0_CR10 S Jaken (BF343282a0_CR14) 1988; 23 BF343282a0_CR12 M Hattori (BF343282a0_CR20) 1983; 152 CA Rouzer (BF343282a0_CR8) 1988; 263 TP Hopp (BF343282a0_CR5) 1981; 78 J Kyte (BF343282a0_CR6) 1982; 157 AS Kraft (BF343282a0_CR13) 1983; 301 EA Ham (BF343282a0_CR21) 1983; 80 H Aviv (BF343282a0_CR17) 1972; 69 CA Rouzer (BF343282a0_CR11) 1988; 263 JM Chargwin (BF343282a0_CR16) 1979; 18 DK Miller (BF343282a0_CR4) 1990; 343 B Samuelsson (BF343282a0_CR1) 1983; 220 RAF Dixon (BF343282a0_CR18) 1986; 321 T Maniatis (BF343282a0_CR19) 1982 JW Gillard (BF343282a0_CR3) 1989; 67 Dixon (BF343282a0_CR22) 1987; 326 B Samuelsson (BF343282a0_CR2) 1987; 237 D Eisenberg (BF343282a0_CR7) 1982; 179 JF Evans (BF343282a0_CR9) 1985; 840 RAF Dixon (BF343282a0_CR15) 1988; 85 |
| References_xml | – volume: 78 start-page: 3824 year: 1981 end-page: 3828 ident: b5 publication-title: Proc. natn. Acad. Sci. U.S.A. contributor: fullname: Woods, K. R. – volume: 85 start-page: 416 year: 1988 end-page: 420 ident: b15 publication-title: Proc. natn. Acad. Sci. U.S.A. contributor: fullname: Dixon, R. A. F. – ident: b12 publication-title: J. biol. Chem. contributor: fullname: Rouzer, C. A. – year: 1984 ident: b10 publication-title: Bulletin contributor: fullname: Yoakim, C. – volume: 179 start-page: 125 year: 1982 end-page: 142 ident: b7 publication-title: J. molec. Biol. contributor: fullname: Wall, R. – volume: 840 start-page: 43 year: 1985 end-page: 50 ident: b9 publication-title: Biochiem. biophys. Acta contributor: fullname: Ford-Hutchinson, A. W. – volume: 157 start-page: 105 year: 1982 end-page: 132 ident: b6 publication-title: J. molec. Biol. contributor: fullname: Doolittle, R. F. – volume: 321 start-page: 75 year: 1986 end-page: 79 ident: b18 publication-title: Nature contributor: fullname: Dixon, R. A. F. – volume: 23 start-page: 243 year: 1988 end-page: 252 ident: b14 publication-title: Ann. Rep. Med. Chem. contributor: fullname: Leach, K. L. – volume: 67 start-page: 456 year: 1989 end-page: 464 ident: b3 publication-title: Can. J. Physiol. Pharmac. contributor: fullname: Gillard, J. W. – volume: 220 start-page: 568 year: 1983 end-page: 575 ident: b1 publication-title: Science contributor: fullname: Samuelsson, B. – volume: 343 start-page: 278 year: 1990 end-page: 281 ident: b4 publication-title: Nature contributor: fullname: Miller, D. K. – volume: 263 start-page: 10980 year: 1988 end-page: 10988 ident: b11 publication-title: J. biol. Chem. contributor: fullname: Kargman, S. – volume: 237 start-page: 1171 year: 1987 end-page: 1176 ident: b2 publication-title: Science contributor: fullname: Serhan, C. N. – year: 1982 ident: b19 article-title: Molecular Cloning: A Laboratory Manual contributor: fullname: Sambrook, J. – volume: 152 start-page: 232 year: 1983 end-page: 238 ident: b20 publication-title: Analyt. Biochem. contributor: fullname: Sakaki, Y. – volume: 80 start-page: 4349 year: 1983 end-page: 4353 ident: b21 publication-title: Proc. natn. Acad. Sci. U.S.A. contributor: fullname: Ham, E. A. – volume: 18 start-page: 5294 year: 1979 end-page: 5299 ident: b16 publication-title: Biochemistry contributor: fullname: Rutter, W. J. – volume: 326 start-page: 73 year: 1987 end-page: 79 ident: b22 publication-title: Nature contributor: fullname: Dixon – volume: 301 start-page: 621 year: 1983 end-page: 622 ident: b13 publication-title: Nature contributor: fullname: Anderson, W. B. – volume: 69 start-page: 1408 year: 1972 end-page: 1412 ident: b17 publication-title: Proc. natn. Acad. Sci. U.S.A. contributor: fullname: Leder, P. – volume: 263 start-page: 10135 year: 1988 end-page: 10140 ident: b8 publication-title: J. biol. Chem. contributor: fullname: Rouzer, C. A. – volume: 80 start-page: 4349 year: 1983 ident: BF343282a0_CR21 publication-title: Proc. natn. Acad. Sci. U.S.A. doi: 10.1073/pnas.80.14.4349 contributor: fullname: EA Ham – volume: 85 start-page: 416 year: 1988 ident: BF343282a0_CR15 publication-title: Proc. natn. Acad. Sci. U.S.A. doi: 10.1073/pnas.85.2.416 contributor: fullname: RAF Dixon – volume: 840 start-page: 43 year: 1985 ident: BF343282a0_CR9 publication-title: Biochiem. biophys. Acta doi: 10.1016/0304-4165(85)90160-6 contributor: fullname: JF Evans – ident: BF343282a0_CR10 – volume: 263 start-page: 10980 year: 1988 ident: BF343282a0_CR11 publication-title: J. biol. Chem. doi: 10.1016/S0021-9258(18)38066-9 contributor: fullname: CA Rouzer – ident: BF343282a0_CR12 – volume: 157 start-page: 105 year: 1982 ident: BF343282a0_CR6 publication-title: J. molec. Biol. doi: 10.1016/0022-2836(82)90515-0 contributor: fullname: J Kyte – volume: 321 start-page: 75 year: 1986 ident: BF343282a0_CR18 publication-title: Nature doi: 10.1038/321075a0 contributor: fullname: RAF Dixon – volume: 326 start-page: 73 year: 1987 ident: BF343282a0_CR22 publication-title: Nature doi: 10.1038/326073a0 contributor: fullname: Dixon – volume: 23 start-page: 243 year: 1988 ident: BF343282a0_CR14 publication-title: Ann. Rep. Med. Chem. contributor: fullname: S Jaken – volume: 343 start-page: 278 year: 1990 ident: BF343282a0_CR4 publication-title: Nature doi: 10.1038/343278a0 contributor: fullname: DK Miller – volume: 69 start-page: 1408 year: 1972 ident: BF343282a0_CR17 publication-title: Proc. natn. Acad. Sci. U.S.A. doi: 10.1073/pnas.69.6.1408 contributor: fullname: H Aviv – volume: 301 start-page: 621 year: 1983 ident: BF343282a0_CR13 publication-title: Nature doi: 10.1038/301621a0 contributor: fullname: AS Kraft – volume: 152 start-page: 232 year: 1983 ident: BF343282a0_CR20 publication-title: Analyt. Biochem. doi: 10.1016/0003-2697(86)90403-3 contributor: fullname: M Hattori – volume: 263 start-page: 10135 year: 1988 ident: BF343282a0_CR8 publication-title: J. biol. Chem. doi: 10.1016/S0021-9258(19)81487-4 contributor: fullname: CA Rouzer – volume: 179 start-page: 125 year: 1982 ident: BF343282a0_CR7 publication-title: J. molec. Biol. doi: 10.1016/0022-2836(84)90309-7 contributor: fullname: D Eisenberg – volume-title: Molecular Cloning: A Laboratory Manual year: 1982 ident: BF343282a0_CR19 contributor: fullname: T Maniatis – volume: 78 start-page: 3824 year: 1981 ident: BF343282a0_CR5 publication-title: Proc. natn. Acad. Sci. U.S.A. doi: 10.1073/pnas.78.6.3824 contributor: fullname: TP Hopp – volume: 18 start-page: 5294 year: 1979 ident: BF343282a0_CR16 publication-title: Biochemistry doi: 10.1021/bi00591a005 contributor: fullname: JM Chargwin – volume: 67 start-page: 456 year: 1989 ident: BF343282a0_CR3 publication-title: Can. J. Physiol. Pharmac. doi: 10.1139/y89-073 contributor: fullname: JW Gillard – volume: 220 start-page: 568 year: 1983 ident: BF343282a0_CR1 publication-title: Science doi: 10.1126/science.6301011 contributor: fullname: B Samuelsson – volume: 237 start-page: 1171 year: 1987 ident: BF343282a0_CR2 publication-title: Science doi: 10.1126/science.2820055 contributor: fullname: B Samuelsson |
| SSID | ssj0005174 |
| Score | 1.9443134 |
| Snippet | Leukotrienes, the biologically active metabolites of arachidonic acid, have been implicated in a variety of inflammatory responses, including asthma, arthritis... LEUKOTRIENES, the biologically active metabolites of arachidonic acid, have been implicated in a variety of inflammatory responses, including asthma, arthritis... Recently a compound, MK-886, has been described that blocks the synthesis of leukotrienes in intact activated leukocytes, but has little or no effect on... Recently, a compound, MK-886, has been described that blocks the synthesis of leukotrienes in intact activated leukocytes, but has little or no effect on... |
| SourceID | proquest crossref pubmed pascalfrancis nature |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 282 |
| SubjectTerms | 5-Lipoxygenase-Activating Proteins Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals Arachidonate 5-lipoxygenase Arachidonate 5-Lipoxygenase - metabolism Arachidonate Lipoxygenases - metabolism Arachidonic acid Arthritis Asthma Base Sequence Biochemistry Biological activity Biological and medical sciences Bone cancer Carrier Proteins Cell Line Cellular biology Complementary DNA Enzymes Fatty acids Fundamental and applied biological sciences. Psychology Gene Expression genes Humans Inflammation Laboratories Leukocytes Leukotrienes Leukotrienes - biosynthesis Lipids Lipoxygenase man Medical research Membrane proteins Membrane Proteins - genetics Membrane Proteins - metabolism Metabolites Molecular Sequence Data Molecules Neutrophils Osteosarcoma Other biological molecules Protein biosynthesis Proteins Psoriasis Rats Sequence Homology, Nucleic Acid Skin diseases Synthesis Transfection |
| Title | Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis |
| URI | http://dx.doi.org/10.1038/343282a0 https://www.ncbi.nlm.nih.gov/pubmed/2300173 https://www.proquest.com/docview/204449801 https://www.proquest.com/docview/2229181858 https://search.proquest.com/docview/15445807 https://search.proquest.com/docview/743423988 https://search.proquest.com/docview/79605451 |
| Volume | 343 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3daxQxEB9siyCI2Gp1bT0j-KAPwctmc0mepJaeRc5SqoV7W7L5KIewe-3egf3vnezXUbF92H1JCGEySX6TmfkNwAcd8825kFRbI6KbMdDCCkXNxBnOuLPBxQTnH2eT08vs-1zMu9icugur7M_E5qB2lY1v5GikZ1mm8Tz9srymsWhUdK52FTS2YIelUkbbS02_bSI8_iFh7rlnufoc0ylVasZ3bqOBS_Pp0tQoodCWtrgfezZ30PQ5POvAIzlqV3sXHvlyDx43QZy23oPdbqPW5GPHJv3pBcwufAz2bV4BSRWIIYLOFsvqzy2qDl5h9Mi2Fc7KK3IeSRsWJUEgS2Z-_buK1bZKT37elogT60X9Ei6nJ7-OT2lXQoFalNaKBjSnZMwC9EG5EFnCC4FrkXqUDn6pV2hOWOm0ctyEVAddMOO4UhMWXKo934ftsir9ayCZHVuTCSEzp2IqtI7cb1nBlBVOOGMTeN-LMl-2TBl54-HmKu_FncCrVsZDj03L6I7QN0PoTKqJ0Akc9KuQd9uszgelSODwP61pqlkEJCqBd0Mzbp_oEzGlr9Z13pARqbFMgNzTAyFWQ5L4wCASzUBEojiL_VY9htmjgYdHHn_z4OQP4AlDUBAfdpg6hO3Vzdq_RaizKkawJecS_-qYjRrlHsHO15Oz84u_3-L_KA |
| link.rule.ids | 315,783,787,12068,12235,12777,21400,27936,27937,31731,31732,33278,33279,33385,33386,33756,33757,43322,43591,43612,43817,74073,74342,74363,74630 |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3daxQxEB-0IgpFbLW69iuCD_oQervZ3CZPUkrLqdsi2kLflmw-5BB2T_cO7H_fmf2qFduHfcoSwmSS-U1m5jcA7zTVmwuZcW2NpDBj4KWVipupMyIWzgZHBc6nZ9PZRfr5Ul72uTlNn1Y53IntRe1qS2_k6KSnaarxPv24-MWpaRQFV_sOGg_hEVp9TedSHf2V4fEPCfPAPSvUAZVTqsRMblmjkUtzfWEalFDoWlvcjT1bG3TyHJ714JEddru9AQ98tQmP2yRO22zCRn9QG_a-Z5P-8ALyb56SfdtXQFYHZpjk-XxR_7lC1UETxg9t1-Gs-sG-EmnDvGIIZFnuVz9r6rZVefb9qkKc2Mybl3Bxcnx-NON9CwVuUVpLHtCdyqgK0AflArGElxL3IvEoHfwSr9CdsJnTygkTEh10GRsnlJrGwSXaiy1Yq-rKvwaW2ok1qZRZ6hSVQmvifkvLWFnppDM2greDKItFx5RRtBFuoYpB3BG86mQ8_nEzsndL6DdT6DRTU6kj2B52oeiPWVOMShHBzn9Gk0THBEhUBPvjMB4fiomYyterpmjJiNQki4Dd8QdCrJYk8Z5JMnQDEYniKrY69RhXjw4eXnnizb2L34cns_PTvMg_nX3ZhqcxAgR65InVDqwtf6_8LsKeZbnXKvc1uC_-kA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3faxQxEB60ohRKsdXWtbWN4IM-hN5uNpfkSUr1qHqWohbubcnmhxzC7tm9A_vfO9nN7lGxfdinLCFMJpNvMjPfALxRod6ccUGV0TyEGT0tDZdUj61mKbPG21Dg_PVifH6Vf57xWaQUamJaZW8TW0NtaxPeyNFJz_NcoT098TEr4vLD5P3iNw0NpEKgNXbTeAiPBDopQeXFTKyzPf4hZO55aJk8CaWVMtOjWzfTwKu5tdANSst3bS7uxqHtfTR5CtsRSJLTbud34IGrduFxm9Bpml3YiYe2IW8js_S7ZzD95kLib_siSGpPNOF0Ol_Uf25QjfA6o6em63ZW_SSXgcBhXhEEtWTqVr_q0HmrcuT7TYWYsZk3z-Fq8vHH2TmN7RSoQcktqUfXSoSKQOel9YExvOS4L5lD6eCXOYmuhRFWScu0z5RXZaotk3Kcepspx_Zgo6or9wJIbkZG55yL3MpQFq0CD1xeptJwy602CbzuRVksOtaMoo12M1n04k5gv5Px8Md65OiW0NdTqFzIMVcJHPS7UMQj1xSDgiRw-J_RLFNpACcygeNhGI9SiI_oytWrpmiJieRIJEDu-APhVkuYeM8kAl1CRKW4ir1OPYbVo7OH5o-9vHfxx_AE9bqYfrr4cgCbKWKF8N6TykPYWF6v3CtEQMvyqNXtvwWBAwM |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Requirement+of+a+5-Lipoxygenase-Activating+Protein+for+Leukotriene+Synthesis&rft.jtitle=Nature+%28London%29&rft.au=Dixon%2C+R+A+F&rft.au=Diehl%2C+R+E&rft.au=Opas%2C+E&rft.au=Rands%2C+E&rft.date=1990-01-18&rft.issn=0028-0836&rft.volume=343&rft.issue=6255&rft.spage=282&rft.epage=282&rft_id=info:doi/10.1038%2F343282a0&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-0836&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-0836&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-0836&client=summon |