Impact of Lipoprotein(a) Level on Low-Density Lipoprotein Cholesterol– or Apolipoprotein B–Related Risk of Coronary Heart Disease

• Published in: Journal of the American College of Cardiology Vol. 84; no. 2; pp. 165 - 177
• Main Authors: Arnold, Natalie, MD, Blaum, Christopher, MD, Goßling, Alina, MSc, Brunner, Fabian J., MD, Bay, Benjamin, MD, Zeller, Tanja, PhD, Ferrario, Marco M., MD, PhD, Brambilla, Paolo, MD, Cesana, Giancarlo, PhD, Leoni, Valerio, MD, Palmieri, Luigi, PhD, Donfrancesco, Chiara, PhD, Ojeda, Francisco, PhD, Linneberg, Allan, MD, Söderberg, Stefan, MD, Iacoviello, Licia, MD, PhD, Gianfagna, Francesco, MD, Costanzo, Simona, PhD, Sans, Susana, MD, PhD, Veronesi, Giovanni, PhD, Thorand, Barbara, PhD, Peters, Annette, PhD, Tunstall-Pedoe, Hugh, MD, Kee, Frank, MD, Salomaa, Veikko, MD, Schnabel, Renate B., MD, Kuulasmaa, Kari, PhD, Blankenberg, Stefan, MD, Waldeyer, Christoph, MD, Koenig, Wolfgang, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.07.2024
• Subjects: Adult; Aged; apolipoprotein B; Apolipoproteins B - blood; Cardiovascular; Cholesterol, LDL - blood; Coronary Disease - blood; Coronary Disease - epidemiology; coronary heart disease; Female; general population; Humans; Incidence; lipoprotein(a); Lipoprotein(a) - blood; low-density lipoprotein; Male; Middle Aged; Risk Assessment - methods; Risk Factors; ASCVD; LDL-C; low-density lipoprotein cholesterol; myocardial infarction; atherosclerotic cardiovascular disease; general population; subdistribution HR; Lp(a); low-density lipoprotein; apoB; HDL-C; oxPL; LDL; high-density lipoprotein cholesterol; coronary heart disease; MI; sHR; apolipoprotein B; lipoprotein(a); CHD; oxidized phospholipid

AbstractBackgroundConventional low-density lipoprotein cholesterol (LDL-C) quantification includes cholesterol attributable to lipoprotein(a) (Lp(a)-C) due to their overlapping densities. ObjectivesThe purposes of this study were to compare the association between LDL-C and LDL-C corrected for Lp(a)...