ApoE genotype: from geographic distribution to function and responsiveness to dietary factors

• Published in: Proceedings of the Nutrition Society Vol. 71; no. 3; pp. 410 - 424
• Main Authors: Egert, Sarah, Rimbach, Gerald, Huebbe, Patricia
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.08.2012
• Subjects: Alzheimer disease; Alzheimer's disease; Animals; Apolipoproteins E - blood; Apolipoproteins E - genetics; biomarkers; blood lipids; Cholesterol; Chronic Disease - prevention & control; chronic diseases; Diet; Europe; Fatty acids; Fatty Acids, Omega-3 - blood; Fatty Acids, Omega-3 - genetics; Fatty Acids, Omega-3 - pharmacology; Flavonoids; Flavonoids - blood; Flavonoids - genetics; Flavonoids - pharmacology; gene frequency; Genotype; Geographical distribution; Health risks; Humans; inflammation; lipid metabolism; Lipids; Lipids - blood; Lipids - genetics; Mediterranean region; Metabolism; mice; Micronutrients - blood; Micronutrients - genetics; Micronutrients - pharmacology; Northern European region; Nutritional Physiological Phenomena - genetics; omega-3 fatty acids; Oxidative stress; Polymorphism, Genetic; Proteins; quercetin; Risk factors; Session IV: Nutritional compounds for optimised healthspan and life performance; Vitamin D; vitamin E; vitamin status; Vitamins; Vitamins - blood; Vitamins - genetics; Vitamins - pharmacology; Europe; Northern European region; Mediterranean region; CVD; ApoE genotype; Flavonoids; n-3 fatty acids; Vitamin D
• ISSN: 0029-6651; 1475-2719; 1475-2719
• DOI: 10.1017/S0029665112000249

ApoE is a key protein in lipid metabolism with three major isoforms. ApoE allele frequencies show non-random global distribution especially in Europe with high apoE ε3 frequency in the Mediterranean area, whereas the apoE ε4 genotype is enriched in Northern Europe. The apoE ε4 genotype is one of the...