Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: A 6-month randomized multicenter trial

• Published in: Journal of allergy and clinical immunology Vol. 98; no. 5; pp. 859 - 871
• Main Authors: Liu, Mark C., Dubé, Louise M., Lancaster, James
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.11.1996; Elsevier
• Subjects: 5-lipoxygenase inhibitors; Adverse effects; antiinflammatory agents; asthma; Biological and medical sciences; bronchial diseases; corticosteroids; leukotrienes; Medical sciences; Pharmacology. Drug treatments; pulmonary function tests; Respiratory system; zileuton; β-agonists; β-agonists; PEFR; bronchial diseases; zileuton; asthma; Adverse effects; 5-lipoxygenase inhibitors; leukotrienes; antiinflammatory agents; FVC; corticosteroids; ANOVA; pulmonary function tests; Human; Respiratory disease; Enzyme; Toxicity; Bronchodilator; Treatment efficiency; Multicenter study; Enzyme inhibitor; Asthma; Zileuton; Chemotherapy; Randomization; Treatment; Arachidonate 5-lipoxygenase; Double blind study; Complication; Clinical trial; Obstructive pulmonary disease; Oxidoreductases

Background: Leukotrienes produced by the 5-lipoxygenase pathway of arachidonic acid metabolism may mediate bronchoconstriction and inflammatory changes important in the pathophysiology of asthma. Leukotriene inhibition may be effective in asthma management. Objective: This clinical trial was perform...