Hemodynamic Factors Driving Peripheral Chemoreceptor Hypersensitivity: Is Severe Aortic Stenosis Treated with Transcatheter Aortic Valve Implantation a Valuable Human Model?

• Published in: Biomedicines Vol. 13; no. 3; p. 611
• Main Authors: Jura, Maksym, Tubek, Stanisław, Reczuch, Jędrzej, Seredyński, Rafał, Niewiński, Piotr, Protasiewicz, Marcin, Ponikowska, Beata, Paleczny, Bartłomiej
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.03.2025; MDPI
• Subjects: Animal models; aortic body; Aortic stenosis; Aortic valve; Aortic valve stenosis; Blood flow; Blood pressure; Body mass index; Care and treatment; Carotid artery; carotid body; Chemoreceptors; Congestive heart failure; Ejection fraction; Enzymes; Health aspects; Heart; Heart rate; Heart valve replacement; Hemodynamics; Hypertension; Hypoxia; Methods; Nitrogen; Patients; peripheral chemoreceptors; peripheral chemoreflex; transcatheter aortic valve implantation; New Zealand; United States > US; transcatheter aortic valve implantation; aortic body; carotid body; aortic stenosis; peripheral chemoreceptors; peripheral chemoreflex

Background: A reduction in carotid artery blood flow (CABF) and ultimately in wall shear stress (WSS) is a major driver of heightened peripheral chemoreceptor (PCh) activity in animal models of heart failure. However, it is yet to be translated to humans. To provide more insight into this matter, we...