The role of mitochondrial sirtuins in health and disease

• Published in: Free radical biology & medicine Vol. 100; pp. 164 - 174
• Main Authors: Osborne, Brenna, Bentley, Nicholas L., Montgomery, Magdalene K., Turner, Nigel
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2016
• Subjects: Acylation; Ageing; Aging; Animals; Humans; Metabolic Diseases - enzymology; Metabolic Diseases - physiopathology; Metabolism; Mitochondria; Mitochondria - enzymology; Mitochondrial Proteins - metabolism; Neoplasms - enzymology; Neoplasms - physiopathology; Neurodegenerative Diseases - enzymology; Neurodegenerative Diseases - physiopathology; Protein Processing, Post-Translational; SIRT3; SIRT4; SIRT5; Sirtuins; Sirtuins - metabolism; Sirtuins; NF-κβ; NAFLD; PTM; GDH; SDHa; mPTP; Mitochondria; OPA1; PDH; HMGCS2; PGC1 α; WT; ANT2/ANT3; BMI; HI/HA; Acylation; NDUFA9; G6PD; KO; NSCLC; TCA cycle; Ageing; IDH2; T2D; STACs; SIRT4; SIRT5; SOD2; Metabolism; CR; MCD; MEF; SOD1; SIRT3; AceCS2; CPS1; ROS; AMPK; LCAD; FOXO3a; ATP; GAPDH; mtHsp60; CtBP; OTC; UOX

Mitochondria play a critical role in energy production, cell signalling and cell survival. Defects in mitochondrial function contribute to the ageing process and ageing-related disorders such as metabolic disease, cancer, and neurodegeneration. The sirtuin family of deacylase enzymes have a variety...