Biotransformation of (–)-Isopulegol by Rhodococcus rhodochrous

The ability of actinobacteria of the genus Rhodococcus to biotransform the monoterpenoid (–)-isopulegol has been established for the first time. R. rhodochrous strain IEGM 1362 was selected as a bacterium capable of metabolizing (–)-isopulegol to form new, previously unknown, 10-hydroxy (2) and 10-c...

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Published inPharmaceuticals (Basel, Switzerland) Vol. 15; no. 8; p. 964
Main Authors Ivshina, Irina B., Luchnikova, Natalia A., Maltseva, Polina Yu, Ilyina, Irina V., Volcho, Konstantin P., Gatilov, Yurii V., Korchagina, Dina V., Kostrikina, Nadezhda A., Sorokin, Vladimir V., Mulyukin, Andrey L., Salakhutdinov, Nariman F.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 03.08.2022
MDPI
Subjects
(–)-isopulegol
Biodegradation
biotransformation
Carbon
Composite materials
Cytotoxicity
Enzymes
halloysite nanotubes
Microorganisms
Microscopy
monoterpenoid
Morphology
Nanoparticles
Physiology
Rhodococcus rhodochrous
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Abstract The ability of actinobacteria of the genus Rhodococcus to biotransform the monoterpenoid (–)-isopulegol has been established for the first time. R. rhodochrous strain IEGM 1362 was selected as a bacterium capable of metabolizing (–)-isopulegol to form new, previously unknown, 10-hydroxy (2) and 10-carboxy (3) derivatives, which may presumably have antitumor activity and act as respiratory stimulants and cancer prevention agents. In the experiments, optimal conditions were selected to provide the maximum target catalytic activity of rhodococci. Using up-to-date (TEM, AFM-CLSM, and EDX) and traditional (cell size, roughness, and zeta potential measurements) biophysical and microbiological methods, it was shown that (–)-isopulegol and halloysite nanotubes did not negatively affect the bacterial cells. The data obtained expand our knowledge of the biocatalytic potential of rhodococci and their possible involvement in the synthesis of pharmacologically active compounds from plant derivatives.
AbstractList The ability of actinobacteria of the genus Rhodococcus to biotransform the monoterpenoid (–)-isopulegol has been established for the first time. R. rhodochrous strain IEGM 1362 was selected as a bacterium capable of metabolizing (–)-isopulegol to form new, previously unknown, 10-hydroxy (2) and 10-carboxy (3) derivatives, which may presumably have antitumor activity and act as respiratory stimulants and cancer prevention agents. In the experiments, optimal conditions were selected to provide the maximum target catalytic activity of rhodococci. Using up-to-date (TEM, AFM-CLSM, and EDX) and traditional (cell size, roughness, and zeta potential measurements) biophysical and microbiological methods, it was shown that (–)-isopulegol and halloysite nanotubes did not negatively affect the bacterial cells. The data obtained expand our knowledge of the biocatalytic potential of rhodococci and their possible involvement in the synthesis of pharmacologically active compounds from plant derivatives.
The ability of actinobacteria of the genus Rhodococcus to biotransform the monoterpenoid (–)-isopulegol has been established for the first time. R . rhodochrous strain IEGM 1362 was selected as a bacterium capable of metabolizing (–)-isopulegol to form new, previously unknown, 10-hydroxy ( 2 ) and 10-carboxy ( 3 ) derivatives, which may presumably have antitumor activity and act as respiratory stimulants and cancer prevention agents. In the experiments, optimal conditions were selected to provide the maximum target catalytic activity of rhodococci. Using up-to-date (TEM, AFM-CLSM, and EDX) and traditional (cell size, roughness, and zeta potential measurements) biophysical and microbiological methods, it was shown that (–)-isopulegol and halloysite nanotubes did not negatively affect the bacterial cells. The data obtained expand our knowledge of the biocatalytic potential of rhodococci and their possible involvement in the synthesis of pharmacologically active compounds from plant derivatives.
The ability of actinobacteria of the genus Rhodococcus to biotransform the monoterpenoid (-)-isopulegol has been established for the first time. R. rhodochrous strain IEGM 1362 was selected as a bacterium capable of metabolizing (-)-isopulegol to form new, previously unknown, 10-hydroxy (2) and 10-carboxy (3) derivatives, which may presumably have antitumor activity and act as respiratory stimulants and cancer prevention agents. In the experiments, optimal conditions were selected to provide the maximum target catalytic activity of rhodococci. Using up-to-date (TEM, AFM-CLSM, and EDX) and traditional (cell size, roughness, and zeta potential measurements) biophysical and microbiological methods, it was shown that (-)-isopulegol and halloysite nanotubes did not negatively affect the bacterial cells. The data obtained expand our knowledge of the biocatalytic potential of rhodococci and their possible involvement in the synthesis of pharmacologically active compounds from plant derivatives.The ability of actinobacteria of the genus Rhodococcus to biotransform the monoterpenoid (-)-isopulegol has been established for the first time. R. rhodochrous strain IEGM 1362 was selected as a bacterium capable of metabolizing (-)-isopulegol to form new, previously unknown, 10-hydroxy (2) and 10-carboxy (3) derivatives, which may presumably have antitumor activity and act as respiratory stimulants and cancer prevention agents. In the experiments, optimal conditions were selected to provide the maximum target catalytic activity of rhodococci. Using up-to-date (TEM, AFM-CLSM, and EDX) and traditional (cell size, roughness, and zeta potential measurements) biophysical and microbiological methods, it was shown that (-)-isopulegol and halloysite nanotubes did not negatively affect the bacterial cells. The data obtained expand our knowledge of the biocatalytic potential of rhodococci and their possible involvement in the synthesis of pharmacologically active compounds from plant derivatives.
Author Korchagina, Dina V.
Luchnikova, Natalia A.
Ivshina, Irina B.
Gatilov, Yurii V.
Sorokin, Vladimir V.
Ilyina, Irina V.
Volcho, Konstantin P.
Maltseva, Polina Yu
Kostrikina, Nadezhda A.
Salakhutdinov, Nariman F.
Mulyukin, Andrey L.
AuthorAffiliation 3 N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences, 9 Lavrentiev Avenue, 630090 Novosibirsk, Russia; ilyina@nioch.nsc.ru (I.V.I.); volcho@nioch.nsc.ru (K.P.V.); gatilov@nioch.nsc.ru (Y.V.G.); verbenon@mail.ru (D.V.K.); anvar@nioch.nsc.ru (N.F.S.)
1 Institute of Ecology and Genetics of Microorganisms of the Ural Branch of the Russian Academy of Sciences, Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences, 13 Golev Str., 614081 Perm, Russia; luchnikova.n@mail.ru
2 Department of Microbiology and Immunology, Perm State National Research University, 15 Bukirev Str., 614990 Perm, Russia; inbox.98@bk.ru
4 Winogradsky Institute of Microbiology, Research Center of Biotechnology, Russian Academy of Sciences, 60 let Oktyabrya, 7, bld. 2, 117312 Moscow, Russia; nadin-kost@yandex.ru (N.A.K.); vlvlsorokin@gmail.com (V.V.S.); andlm@mail.ru (A.L.M.)
AuthorAffiliation_xml – name: 3 N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences, 9 Lavrentiev Avenue, 630090 Novosibirsk, Russia; ilyina@nioch.nsc.ru (I.V.I.); volcho@nioch.nsc.ru (K.P.V.); gatilov@nioch.nsc.ru (Y.V.G.); verbenon@mail.ru (D.V.K.); anvar@nioch.nsc.ru (N.F.S.)
– name: 4 Winogradsky Institute of Microbiology, Research Center of Biotechnology, Russian Academy of Sciences, 60 let Oktyabrya, 7, bld. 2, 117312 Moscow, Russia; nadin-kost@yandex.ru (N.A.K.); vlvlsorokin@gmail.com (V.V.S.); andlm@mail.ru (A.L.M.)
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Snippet The ability of actinobacteria of the genus Rhodococcus to biotransform the monoterpenoid (–)-isopulegol has been established for the first time. R. rhodochrous...
The ability of actinobacteria of the genus Rhodococcus to biotransform the monoterpenoid (-)-isopulegol has been established for the first time. R. rhodochrous...
The ability of actinobacteria of the genus Rhodococcus to biotransform the monoterpenoid (–)-isopulegol has been established for the first time. R ....
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StartPage 964
SubjectTerms (–)-isopulegol
Biodegradation
biotransformation
Carbon
Composite materials
Cytotoxicity
Enzymes
halloysite nanotubes
Microorganisms
Microscopy
monoterpenoid
Morphology
Nanoparticles
Physiology
Rhodococcus rhodochrous
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Title Biotransformation of (–)-Isopulegol by Rhodococcus rhodochrous
URI https://www.proquest.com/docview/2706272326
https://www.proquest.com/docview/2707600719
https://pubmed.ncbi.nlm.nih.gov/PMC9412403
https://doaj.org/article/b67f09e12dc44c219c1d7906aca042ab
Volume 15
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