The Immune Receptor NOD1 and Kinase RIP2 Interact with Bacterial Peptidoglycan on Early Endosomes to Promote Autophagy and Inflammatory Signaling

• Published in: Cell host & microbe Vol. 15; no. 5; pp. 623 - 635
• Main Authors: Irving, Aaron T., Mimuro, Hitomi, Kufer, Thomas A., Lo, Camden, Wheeler, Richard, Turner, Lorinda J., Thomas, Belinda J., Malosse, Christian, Gantier, Michael P., Casillas, Linda N., Votta, Bartholomew J., Bertin, John, Boneca, Ivo G., Sasakawa, Chihiro, Philpott, Dana J., Ferrero, Richard L., Kaparakis-Liaskos, Maria
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.05.2014
• Subjects: Animals; Autophagy; Cell Line; Endosomes - immunology; Endosomes - microbiology; Helicobacter Infections - enzymology; Helicobacter Infections - genetics; Helicobacter Infections - immunology; Helicobacter pylori - immunology; Helicobacter pylori - physiology; Humans; Mice; Nod1 Signaling Adaptor Protein - genetics; Nod1 Signaling Adaptor Protein - immunology; Peptidoglycan - immunology; Protein Binding; Pseudomonas aeruginosa - immunology; Pseudomonas aeruginosa - physiology; Pseudomonas Infections - enzymology; Pseudomonas Infections - genetics; Pseudomonas Infections - immunology; Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics; Receptor-Interacting Protein Serine-Threonine Kinase 2 - immunology; Receptors, Immunologic - genetics; Receptors, Immunologic - immunology; Signal Transduction

The intracellular innate immune receptor NOD1 detects Gram-negative bacterial peptidoglycan (PG) to induce autophagy and inflammatory responses in host cells. To date, the intracellular compartment in which PG is detected by NOD1 and whether NOD1 directly interacts with PG are two questions that rem...