Chromatin Structure and Dynamics: Focus on Neuronal Differentiation and Pathological Implication

Chromatin structure is an essential regulator of gene expression. Its state of compaction contributes to the regulation of genetic programs, in particular during differentiation. Epigenetic processes, which include post-translational modifications of histones, DNA methylation and implication of non-...

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Published inGenes Vol. 13; no. 4; p. 639
Main Authors Nothof, Sophie A, Magdinier, Frédérique, Van-Gils, Julien
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 02.04.2022
MDPI
Subjects
Amino acids
Biochemistry, Molecular Biology
Cell cycle
Central nervous system
Chromatin
Chromatin - genetics
Development Biology
DNA methylation
DNA Methylation - genetics
Epigenesis, Genetic
Epigenetics
Gene expression
Genomes
Genomics
Histones
Histones - metabolism
Life Sciences
Molecular weight
Neurobiology
Neurogenesis
Neurons and Cognition
Non-coding RNA
Photoreceptors
Post-translation
Protein Processing, Post-Translational - genetics
Proteins
Review
Translation
acetylation
histone modification
methylation
chromatin
chromatinopathies
epigenetics
neuronal differentiation
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Abstract Chromatin structure is an essential regulator of gene expression. Its state of compaction contributes to the regulation of genetic programs, in particular during differentiation. Epigenetic processes, which include post-translational modifications of histones, DNA methylation and implication of non-coding RNA, are powerful regulators of gene expression. Neurogenesis and neuronal differentiation are spatio-temporally regulated events that allow the formation of the central nervous system components. Here, we review the chromatin structure and post-translational histone modifications associated with neuronal differentiation. Studying the impact of histone modifications on neuronal differentiation improves our understanding of the pathophysiological mechanisms of chromatinopathies and opens up new therapeutic avenues. In addition, we will discuss techniques for the analysis of histone modifications on a genome-wide scale and the pathologies associated with the dysregulation of the epigenetic machinery.
AbstractList Chromatin structure is an essential regulator of gene expression. Its state of compaction contributes to the regulation of genetic programs, in particular during differentiation. Epigenetic processes, which include post-translational modifications of histones, DNA methylation and implication of non-coding RNA, are powerful regulators of gene expression. Neurogenesis and neuronal differentiation are spatio-temporally regulated events that allow the formation of the central nervous system components. Here, we review the chromatin structure and post-translational histone modifications associated with neuronal differentiation. Studying the impact of histone modifications on neuronal differentiation improves our understanding of the pathophysiological mechanisms of chromatinopathies and opens up new therapeutic avenues. In addition, we will discuss techniques for the analysis of histone modifications on a genome-wide scale and the pathologies associated with the dysregulation of the epigenetic machinery.
Author Nothof, Sophie A
Van-Gils, Julien
Magdinier, Frédérique
AuthorAffiliation 1 Marseille Medical Genetics, Aix Marseille University, Inserm, CEDEX 05, 13385 Marseille, France; sophie.nothof@etu.univ-amu.fr (S.A.N.); frederique.magdinier@univ-amu.fr (F.M.)
2 Reference Center AD SOOR, AnDDI-RARE, Inserm U 1211, Medical Genetics Department, Bordeaux University, Center Hospitalier Universitaire de Bordeaux, 33076 Bordeaux, France
AuthorAffiliation_xml – name: 2 Reference Center AD SOOR, AnDDI-RARE, Inserm U 1211, Medical Genetics Department, Bordeaux University, Center Hospitalier Universitaire de Bordeaux, 33076 Bordeaux, France
– name: 1 Marseille Medical Genetics, Aix Marseille University, Inserm, CEDEX 05, 13385 Marseille, France; sophie.nothof@etu.univ-amu.fr (S.A.N.); frederique.magdinier@univ-amu.fr (F.M.)
Author_xml – sequence: 1
  givenname: Sophie A
  orcidid: 0000-0002-6440-2258
  surname: Nothof
  fullname: Nothof, Sophie A
  organization: Marseille Medical Genetics, Aix Marseille University, Inserm, CEDEX 05, 13385 Marseille, France
– sequence: 2
  givenname: Frédérique
  orcidid: 0000-0002-0159-9559
  surname: Magdinier
  fullname: Magdinier, Frédérique
  organization: Marseille Medical Genetics, Aix Marseille University, Inserm, CEDEX 05, 13385 Marseille, France
– sequence: 3
  givenname: Julien
  orcidid: 0000-0003-1497-9363
  surname: Van-Gils
  fullname: Van-Gils, Julien
  organization: Reference Center AD SOOR, AnDDI-RARE, Inserm U 1211, Medical Genetics Department, Bordeaux University, Center Hospitalier Universitaire de Bordeaux, 33076 Bordeaux, France
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35456445$$D View this record in MEDLINE/PubMed
https://hal.science/hal-03678849$$DView record in HAL
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Issue 4
Keywords acetylation
histone modification
methylation
chromatin
chromatinopathies
epigenetics
neuronal differentiation
Language English
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Snippet Chromatin structure is an essential regulator of gene expression. Its state of compaction contributes to the regulation of genetic programs, in particular...
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SubjectTerms Amino acids
Biochemistry, Molecular Biology
Cell cycle
Central nervous system
Chromatin
Chromatin - genetics
Development Biology
DNA methylation
DNA Methylation - genetics
Epigenesis, Genetic
Epigenetics
Gene expression
Genomes
Genomics
Histones
Histones - metabolism
Life Sciences
Molecular weight
Neurobiology
Neurogenesis
Neurons and Cognition
Non-coding RNA
Photoreceptors
Post-translation
Protein Processing, Post-Translational - genetics
Proteins
Review
Translation
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Title Chromatin Structure and Dynamics: Focus on Neuronal Differentiation and Pathological Implication
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Volume 13
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