Optimizing global liver function in radiation therapy treatment planning

• Published in: Physics in medicine & biology Vol. 61; no. 17; pp. 6465 - 6484
• Main Authors: Wu, Victor W, Epelman, Marina A, Wang, Hesheng, Edwin Romeijn, H, Feng, Mary, Cao, Yue, Ten Haken, Randall K, Matuszak, Martha M
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 07.09.2016
• Subjects: dose-response; functional imaging; Humans; Liver - radiation effects; liver SBRT; Magnetic Resonance Imaging - methods; optimization; Perfusion Imaging - methods; Radiation Tolerance; Radiosurgery - methods; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted - methods; treatment planning

Liver stereotactic body radiation therapy (SBRT) patients differ in both pre-treatment liver function (e.g. due to degree of cirrhosis and/or prior treatment) and radiosensitivity, leading to high variability in potential liver toxicity with similar doses. This work investigates three treatment plan...