Cartilage defects are associated with physical disability in obese adults
Objective. To describe the associations between physical disability measures and knee cartilage defects in obese adults. Methods. One hundred and eleven obese subjects were recruited from laparoscopic adjustable gastric banding or exercise/diet weight loss programmes. All subjects completed disease-...
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Published in | Rheumatology (Oxford, England) Vol. 48; no. 10; pp. 1290 - 1293 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Oxford University Press
01.10.2009
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Abstract | Objective. To describe the associations between physical disability measures and knee cartilage defects in obese adults. Methods. One hundred and eleven obese subjects were recruited from laparoscopic adjustable gastric banding or exercise/diet weight loss programmes. All subjects completed disease-specific (WOMAC) and general health status (SF-36) questionnaires, and were assessed for range of knee motion, tibiofemoral alignment and quadriceps strength. Knee cartilage defects were graded on MRI according to established protocol. Regression analysis was adjusted for age, gender, BMI and presence of clinical knee OA. Results. The association between higher whole compartment cartilage defect scores and increasing BMI, age and clinical knee OA was confirmed in this obese cohort (r = 0.27, P = 0.01; r = 0.26, P = 0.007; P < 0.0001, respectively), whereas new associations were found with reduced knee range of motion (r = 0.5, P < 0.0001). No associations were found between defect scores and quadriceps strength. Varus malalignment was associated with higher medial cartilage defect scores (r = 0.33, P = 0.013). Higher levels of pain, stiffness and physical disability (WOMAC, SF-36) were associated with higher medial compartment and patella cartilage defect scores. Conclusions. Knee cartilage defects increase with increasing obesity and are associated with both objective and self-reported measures of physical disability. Longitudinal studies are required to assess the potential for change or improvement in cartilage defects with weight loss. |
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AbstractList | Objective. To describe the associations between physical disability measures and knee cartilage defects in obese adults.Methods. One hundred and eleven obese subjects were recruited from laparoscopic adjustable gastric banding or exercise/diet weight loss programmes. All subjects completed disease-specific (WOMAC) and general health status (SF-36) questionnaires, and were assessed for range of knee motion, tibiofemoral alignment and quadriceps strength. Knee cartilage defects were graded on MRI according to established protocol. Regression analysis was adjusted for age, gender, BMI and presence of clinical knee OA.Results. The association between higher whole compartment cartilage defect scores and increasing BMI, age and clinical knee OA was confirmed in this obese cohort (r = 0.27, P = 0.01; r = 0.26, P = 0.007; P < 0.0001, respectively), whereas new associations were found with reduced knee range of motion (r = 0.5, P < 0.0001). No associations were found between defect scores and quadriceps strength. Varus malalignment was associated with higher medial cartilage defect scores (r = 0.33, P = 0.013). Higher levels of pain, stiffness and physical disability (WOMAC, SF-36) were associated with higher medial compartment and patella cartilage defect scores.Conclusions. Knee cartilage defects increase with increasing obesity and are associated with both objective and self-reported measures of physical disability. Longitudinal studies are required to assess the potential for change or improvement in cartilage defects with weight loss. To describe the associations between physical disability measures and knee cartilage defects in obese adults. One hundred and eleven obese subjects were recruited from laparoscopic adjustable gastric banding or exercise/diet weight loss programmes. All subjects completed disease-specific (WOMAC) and general health status (SF-36) questionnaires, and were assessed for range of knee motion, tibiofemoral alignment and quadriceps strength. Knee cartilage defects were graded on MRI according to established protocol. Regression analysis was adjusted for age, gender, BMI and presence of clinical knee OA. The association between higher whole compartment cartilage defect scores and increasing BMI, age and clinical knee OA was confirmed in this obese cohort (r = 0.27, P = 0.01; r = 0.26, P = 0.007; P < 0.0001, respectively), whereas new associations were found with reduced knee range of motion (r = 0.5, P < 0.0001). No associations were found between defect scores and quadriceps strength. Varus malalignment was associated with higher medial cartilage defect scores (r = 0.33, P = 0.013). Higher levels of pain, stiffness and physical disability (WOMAC, SF-36) were associated with higher medial compartment and patella cartilage defect scores. Knee cartilage defects increase with increasing obesity and are associated with both objective and self-reported measures of physical disability. Longitudinal studies are required to assess the potential for change or improvement in cartilage defects with weight loss. OBJECTIVETo describe the associations between physical disability measures and knee cartilage defects in obese adults.METHODSOne hundred and eleven obese subjects were recruited from laparoscopic adjustable gastric banding or exercise/diet weight loss programmes. All subjects completed disease-specific (WOMAC) and general health status (SF-36) questionnaires, and were assessed for range of knee motion, tibiofemoral alignment and quadriceps strength. Knee cartilage defects were graded on MRI according to established protocol. Regression analysis was adjusted for age, gender, BMI and presence of clinical knee OA.RESULTSThe association between higher whole compartment cartilage defect scores and increasing BMI, age and clinical knee OA was confirmed in this obese cohort (r = 0.27, P = 0.01; r = 0.26, P = 0.007; P < 0.0001, respectively), whereas new associations were found with reduced knee range of motion (r = 0.5, P < 0.0001). No associations were found between defect scores and quadriceps strength. Varus malalignment was associated with higher medial cartilage defect scores (r = 0.33, P = 0.013). Higher levels of pain, stiffness and physical disability (WOMAC, SF-36) were associated with higher medial compartment and patella cartilage defect scores.CONCLUSIONSKnee cartilage defects increase with increasing obesity and are associated with both objective and self-reported measures of physical disability. Longitudinal studies are required to assess the potential for change or improvement in cartilage defects with weight loss. |
Author | Giuffre, Bruno Sambrook, Philip Leibman, Steven Caterson, Ian Anandacoomarasamy, Ananthila Smith, Garett Fransen, Marlene March, Lyn |
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Keywords | Human Motion Obesity Range of motion MRI Quadriceps strength Diseases of the osteoarticular system Nutrition disorder Rheumatology Nuclear magnetic resonance imaging Clinical osteoarthritis Disability Cartilage Alignment Cartilage defects Arthropathy Quadriceps muscle Medical imagery Adult Degenerative disease Osteoarthritis Nutritional status Strength |
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References | (1_35417936) 2008; 32 Ding (16_18698434) 2005; 13 Ding (17_18737701) 2005; 64 Szoeke (3_22620879) 2006; 33 Spector (2_15681144) 1994; 53 Hopman-Rock (10_10443587) 2000; 27 Brazier (14_9952959) 1992; 305 Altman (15_13904222) 1986; 29 Kraus (9_19085650) 2005; 52 (23_29483156) 2006; 14 Anandacoomarasamy (22_33387230) 2009; 21 Ding (4_28534890) 2007; 15 Hanna (5_23716915) 2007; 57 (8_35417937) 2008; 16 Williams (12_19511171) 2005; 52 Buckwalter (21_15877468) 1995; 43 Liikavainio (11_32590929) 2008; 89 Ding (6_18769489) 2005; 13 Ding (7_21804943) 2006; 166 Bellamy (13_5166705) 1988; 15 Arokoski (19_10392251) 2000; 10 Vanwanseele (18_17069851) 2002; 10 Radin (20_9752982) 1991; 21 |
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Snippet | Objective. To describe the associations between physical disability measures and knee cartilage defects in obese adults. Methods. One hundred and eleven obese... To describe the associations between physical disability measures and knee cartilage defects in obese adults. One hundred and eleven obese subjects were... Objective. To describe the associations between physical disability measures and knee cartilage defects in obese adults.Methods. One hundred and eleven obese... OBJECTIVETo describe the associations between physical disability measures and knee cartilage defects in obese adults.METHODSOne hundred and eleven obese... |
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SubjectTerms | Adult Alignment Biological and medical sciences Cartilage defects Cartilage Diseases - etiology Cartilage Diseases - pathology Cartilage Diseases - physiopathology Cartilage, Articular - pathology Clinical osteoarthritis Cross-Sectional Studies Disability Evaluation Diseases of the osteoarticular system Female Humans Knee Joint - pathology Knee Joint - physiopathology Magnetic Resonance Imaging Male Medical sciences Metabolic diseases Middle Aged Miscellaneous. Osteoarticular involvement in other diseases MRI Muscle Strength Muscle, Skeletal - physiopathology Obesity Obesity - complications Osteoarthritis Osteoarthritis, Knee - etiology Osteoarthritis, Knee - pathology Osteoarthritis, Knee - physiopathology Quadriceps strength Range of motion Range of Motion, Articular Severity of Illness Index |
Title | Cartilage defects are associated with physical disability in obese adults |
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