Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study

• Published in: British journal of psychiatry Vol. 182; no. 5; pp. 439 - 443
• Main Authors: Burns, J., Job, D., Bastin, M. E., Whalley, H., Macgillivray, T., Johnstone, E. C., Lawrie, S M.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.05.2003; RCP
• Subjects: Anisotropy; Attention deficit hyperactivity disorder; Brain Mapping - methods; Brain research; Case-Control Studies; Cerebral Cortex - pathology; Cingulum; Cortex; Diffusion tensor imaging; Frontotemporal; Humans; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - statistics & numerical data; Medical imaging; Mental disorders; Morality; Morphometry; Neural networks; Neural Pathways - pathology; NMR; Nuclear magnetic resonance; Psychiatry; Psychotropic drugs; Research subjects; Schizophrenia; Schizophrenia - pathology; Substantia alba; United Kingdom > UK; United States > US; Scotland

There is growing evidence that schizophrenia is a disorder of cortical connectivity. Specifically, frontotemporal and frontoparietal connections are thought to be functionally impaired. Diffusion tensor magnetic resonance imaging (DT-MRI) is a technique that has the potential to demonstrate structur...