Epidemiology and Clinical Manifestations of Unique Chlamydia trachomatis Isolates That Occupy Nonfusogenic Inclusions
Unique Chlamydia trachomatis strains characterized by multiple nonfusing inclusions were recently described. These strains lack evidence of the protein IncA in the inclusion membrane and have mutations in the incA gene. This study evaluated the epidemiology and clinical manifestations of patients in...
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Published in | The Journal of infectious diseases Vol. 184; no. 7; pp. 879 - 884 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Chicago, IL
The University of Chicago Press
01.10.2001
University of Chicago Press Oxford University Press |
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Abstract | Unique Chlamydia trachomatis strains characterized by multiple nonfusing inclusions were recently described. These strains lack evidence of the protein IncA in the inclusion membrane and have mutations in the incA gene. This study evaluated the epidemiology and clinical manifestations of patients infected with nonfusing mutant strains (case patients) and compared them with patients infected with wild-type fusing strains (control subjects). Both male and female case patients had fewer signs of infection than did control subjects (P=.016 and P=.019, respectively). Female case patients also had fewer symptoms of infection (P=.02). Median inclusion-forming unit (ifu) counts were lower in male and female case patients (P=.045 and P=.135, respectively). Thus, nonfusing strains of C. trachomatis more often produce subclinical infections than do normal fusing strains and have lower median ifu counts. From a prevention perspective, the data underscore the importance of screening programs to detect and treat inapparent C. trachomatis infection |
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AbstractList | Unique Chlamydia trachomatis strains characterized by multiple nonfusing inclusions were recently described. These strains lack evidence of the protein IncA in the inclusion membrane and have mutations in the incA gene. This study evaluated the epidemiology and clinical manifestations of patients infected with nonfusing mutant strains (case patients) and compared them with patients infected with wild-type fusing strains (control subjects). Both male and female case patients had fewer signs of infection than did control subjects (P=.016 and P=.019, respectively). Female case patients also had fewer symptoms of infection (P=.02). Median inclusion-forming unit (ifu) counts were lower in male and female case patients (P=.045 and P=.135, respectively). Thus, nonfusing strains of C. trachomatis more often produce subclinical infections than do normal fusing strains and have lower median ifu counts. From a prevention perspective, the data underscore the importance of screening programs to detect and treat inapparent C. trachomatis infection. Unique Chlamydia trachomatis strains characterized by multiple nonfusing inclusions were recently described. These strains lack evidence of the protein IncA in the inclusion membrane and have mutations in the incA gene. This study evaluated the epidemiology and clinical manifestations of patients infected with nonfusing mutant strains (case patients) and compared them with patients infected with wild-type fusing strains (control subjects). Both male and female case patients had fewer signs of infection than did control subjects (P=.016 and P=.019, respectively). Female case patients also had fewer symptoms of infection (P=.02). Median inclusion-forming unit (ifu) counts were lower in male and female case patients (P=.045 and P=.135, respectively). Thus, nonfusing strains of C. trachomatis more often produce subclinical infections than do normal fusing strains and have lower median ifu counts. From a prevention perspective, the data underscore the importance of screening programs to detect and treat inapparent C. trachomatis infection |
Author | Stamm, Walter E. Rockey, Daniel D. Geisler, William M. Suchland, Robert J. |
Author_xml | – sequence: 1 givenname: William M. surname: Geisler fullname: Geisler, William M. organization: Division of Allergy and Infectious Diseases, School of Medicine, University of Washington, Seattle – sequence: 2 givenname: Robert J. surname: Suchland fullname: Suchland, Robert J. organization: Division of Allergy and Infectious Diseases, School of Medicine, University of Washington, Seattle – sequence: 3 givenname: Daniel D. surname: Rockey fullname: Rockey, Daniel D. organization: Department of Microbiology, Oregon State University, Corvallis – sequence: 4 givenname: Walter E. surname: Stamm fullname: Stamm, Walter E. email: wes@u.washington.edu organization: Division of Allergy and Infectious Diseases, School of Medicine, University of Washington, Seattle |
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Keywords | Human Prevention Membrane protein Chlamydiaceae Gene Chlamydiales Bacteria Female Isolate Chlamydia trachomatis Mutation Epidemiology |
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SubjectTerms | Adolescent Adult Atherosclerosis (general aspects, experimental research) Bacterial diseases Bacterial diseases of the genital system Bacterial Proteins - genetics Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Case-Control Studies Chlamydia Infections - epidemiology Chlamydia Infections - microbiology Chlamydia Infections - pathology Chlamydia trachomatis Chlamydia trachomatis - classification Chlamydia trachomatis - genetics Dysuria Epidemiology Ethnic Groups Female Female Urogenital Diseases - epidemiology Female Urogenital Diseases - microbiology Female Urogenital Diseases - pathology Genitalia Human bacterial diseases Humans IncA protein Incan culture Inclusion Bodies - microbiology Inclusion Bodies - pathology Infections Infectious diseases Logistic Models Major Articles Male Male Urogenital Diseases Medical sciences Mutation Phenotypes Phosphoproteins - genetics Serotyping Sexually Transmitted Diseases - epidemiology Sexually Transmitted Diseases - microbiology Sexually Transmitted Diseases - pathology Symptoms Washington - epidemiology |
Title | Epidemiology and Clinical Manifestations of Unique Chlamydia trachomatis Isolates That Occupy Nonfusogenic Inclusions |
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