Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes - Nejat, Shadi; Menikdiwela, Kalhara R.; Efotte, Aliyah; Scoggin, Shane; Vandanmagsar, Bolormaa; Thornalley, Paul J.; Dehbi, Mohammed; Moustaid-Moussa, Naima (Genes, 2023)
Keywords: Adipose tissue; Biomedical research; Body composition; Body fat; Body weight; chemokine CCL2; Chemokines; Chronic illnesses; CRISPR; CRISPR-Cas systems; Dextrose; Diabetes; Diabetes mellitus (non-insulin dependent); diet; Disease; Endoplasmic reticulum; euthanasia; females; Gene expression; Genes; Genetic aspects; Glucose; Glucose metabolism; Glucose tolerance; Glucose tolerance tests; GLUT4 gene; Heat shock proteins; High fat diet; Homeostasis; humans; Inflammation; Insulin; Insulin resistance; insulin tolerance test; Laboratory animals; males; Metabolism; mice; Muscles; NMR; noninsulin-dependent diabetes mellitus; Nuclear magnetic resonance; nuclear magnetic resonance spectroscopy; Obesity; phenotype; Phenotypes; Phenotyping; protective effect; RNA; Skeletal muscle; Therapeutic targets; therapeutics; Tumor necrosis factor-α; Type 2 diabetes; white adipose tissue; United States--US