Histidine Kinase Sln1 and cAMP/PKA Signaling Pathways Antagonistically Regulate Sporisorium scitamineum Mating and Virulence via Transcription Factor Prf1
Many prokaryotes and eukaryotes utilize two-component signaling pathways to counter environmental stress and regulate virulence genes associated with infection. In this study, we identified and characterized a conserved histidine kinase (SsSln1), which is the sensor of the two-component system of Sl...
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| Published in | Journal of fungi (Basel) Vol. 7; no. 8; p. 610 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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28.07.2021
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| Abstract | Many prokaryotes and eukaryotes utilize two-component signaling pathways to counter environmental stress and regulate virulence genes associated with infection. In this study, we identified and characterized a conserved histidine kinase (SsSln1), which is the sensor of the two-component system of Sln1–Ypd1–Ssk1 in Sporisorium scitamineum. SsSln1 null mutant exhibited enhanced mating and virulence capabilities in S. scitamineum, which is opposite to what has been reported in Candida albicans. Further investigations revealed that the deletion of SsSLN1 enhanced SsHog1 phosphorylation and nuclear localization and thus promoted S. scitamineum mating. Interestingly, SsSln1 and cAMP/PKA signaling pathways antagonistically regulated the transcription of pheromone-responsive transcription factor SsPrf1, for regulating S. scitamineum mating and virulence. In short, the study depicts a novel mechanism in which the cross-talk between SsSln1 and cAMP/PKA pathways antagonistically regulates mating and virulence by balancing the transcription of the SsPRF1 gene in S. scitamineum. |
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| AbstractList | Many prokaryotes and eukaryotes utilize two-component signaling pathways to counter environmental stress and regulate virulence genes associated with infection. In this study, we identified and characterized a conserved histidine kinase (SsSln1), which is the sensor of the two-component system of Sln1–Ypd1–Ssk1 in Sporisorium scitamineum. SsSln1 null mutant exhibited enhanced mating and virulence capabilities in S. scitamineum, which is opposite to what has been reported in Candida albicans. Further investigations revealed that the deletion of SsSLN1 enhanced SsHog1 phosphorylation and nuclear localization and thus promoted S. scitamineum mating. Interestingly, SsSln1 and cAMP/PKA signaling pathways antagonistically regulated the transcription of pheromone-responsive transcription factor SsPrf1, for regulating S. scitamineum mating and virulence. In short, the study depicts a novel mechanism in which the cross-talk between SsSln1 and cAMP/PKA pathways antagonistically regulates mating and virulence by balancing the transcription of the SsPRF1 gene in S. scitamineum. Many prokaryotes and eukaryotes utilize two-component signaling pathways to counter environmental stress and regulate virulence genes associated with infection. In this study, we identified and characterized a conserved histidine kinase (SsSln1), which is the sensor of the two-component system of Sln1-Ypd1-Ssk1 in Sporisorium scitamineum. SsSln1 null mutant exhibited enhanced mating and virulence capabilities in S. scitamineum, which is opposite to what has been reported in Candida albicans. Further investigations revealed that the deletion of SsSLN1 enhanced SsHog1 phosphorylation and nuclear localization and thus promoted S. scitamineum mating. Interestingly, SsSln1 and cAMP/PKA signaling pathways antagonistically regulated the transcription of pheromone-responsive transcription factor SsPrf1, for regulating S. scitamineum mating and virulence. In short, the study depicts a novel mechanism in which the cross-talk between SsSln1 and cAMP/PKA pathways antagonistically regulates mating and virulence by balancing the transcription of the SsPRF1 gene in S. scitamineum.Many prokaryotes and eukaryotes utilize two-component signaling pathways to counter environmental stress and regulate virulence genes associated with infection. In this study, we identified and characterized a conserved histidine kinase (SsSln1), which is the sensor of the two-component system of Sln1-Ypd1-Ssk1 in Sporisorium scitamineum. SsSln1 null mutant exhibited enhanced mating and virulence capabilities in S. scitamineum, which is opposite to what has been reported in Candida albicans. Further investigations revealed that the deletion of SsSLN1 enhanced SsHog1 phosphorylation and nuclear localization and thus promoted S. scitamineum mating. Interestingly, SsSln1 and cAMP/PKA signaling pathways antagonistically regulated the transcription of pheromone-responsive transcription factor SsPrf1, for regulating S. scitamineum mating and virulence. In short, the study depicts a novel mechanism in which the cross-talk between SsSln1 and cAMP/PKA pathways antagonistically regulates mating and virulence by balancing the transcription of the SsPRF1 gene in S. scitamineum. Many prokaryotes and eukaryotes utilize two-component signaling pathways to counter environmental stress and regulate virulence genes associated with infection. In this study, we identified and characterized a conserved histidine kinase (SsSln1), which is the sensor of the two-component system of Sln1–Ypd1–Ssk1 in Sporisorium scitamineum . SsSln1 null mutant exhibited enhanced mating and virulence capabilities in S. scitamineum , which is opposite to what has been reported in Candida albicans . Further investigations revealed that the deletion of SsSLN1 enhanced SsHog1 phosphorylation and nuclear localization and thus promoted S. scitamineum mating. Interestingly, SsSln1 and cAMP/PKA signaling pathways antagonistically regulated the transcription of pheromone-responsive transcription factor SsPrf1, for regulating S. scitamineum mating and virulence. In short, the study depicts a novel mechanism in which the cross-talk between SsSln1 and cAMP/PKA pathways antagonistically regulates mating and virulence by balancing the transcription of the SsPRF1 gene in S. scitamineum . |
| Author | Jiang, Zide Huang, Peishen Cai, Enping Sun, Xian Sun, Shuquan Deng, Yizhen Wang, Yuting Chang, Changqing |
| AuthorAffiliation | 1 College of Plant Protection, South China Agricultural University, Guangzhou 510642, China; dlcep@foxmail.com (E.C.); sunshuquan@yrcti.edu.cn (S.S.); dengyz@scau.edu.cn (Y.D.); hps547384492@gmail.com (P.H.); sunx2021@163.com (X.S.) 2 Integrate Microbiology Research Center, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou 510642, China; yutingwbio@163.com 3 Environmental Monitoring and Remediation Engineering Technology Research Center, School of Environmental Engineering, Yellow River Conservancy Technical Institute, Kaifeng 475004, China |
| AuthorAffiliation_xml | – name: 3 Environmental Monitoring and Remediation Engineering Technology Research Center, School of Environmental Engineering, Yellow River Conservancy Technical Institute, Kaifeng 475004, China – name: 1 College of Plant Protection, South China Agricultural University, Guangzhou 510642, China; dlcep@foxmail.com (E.C.); sunshuquan@yrcti.edu.cn (S.S.); dengyz@scau.edu.cn (Y.D.); hps547384492@gmail.com (P.H.); sunx2021@163.com (X.S.) – name: 2 Integrate Microbiology Research Center, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou 510642, China; yutingwbio@163.com |
| Author_xml | – sequence: 1 givenname: Enping surname: Cai fullname: Cai, Enping – sequence: 2 givenname: Shuquan surname: Sun fullname: Sun, Shuquan – sequence: 3 givenname: Yizhen surname: Deng fullname: Deng, Yizhen – sequence: 4 givenname: Peishen surname: Huang fullname: Huang, Peishen – sequence: 5 givenname: Xian surname: Sun fullname: Sun, Xian – sequence: 6 givenname: Yuting surname: Wang fullname: Wang, Yuting – sequence: 7 givenname: Changqing orcidid: 0000-0002-5301-2932 surname: Chang fullname: Chang, Changqing – sequence: 8 givenname: Zide surname: Jiang fullname: Jiang, Zide |
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