SOX2 Expression Does Not Guarantee Cancer Stem Cell-like Characteristics in Lung Adenocarcinoma

• Published in: Cells (Basel, Switzerland) Vol. 13; no. 3; p. 216
• Main Authors: Bae, Seung-Hyun, Lee, Kyung Yong, Han, Suji, Yun, Chul Won, Park, ChanHyeok, Jang, Hyonchol
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2024
• Subjects: Adenocarcinoma; cancer stem cell-like properties; Cancer therapies; Care and treatment; CRISPR; CRISPR/Cas9; Flow cytometry; Gene amplification; Genetic aspects; lung adenocarcinoma; Lung cancer; Lung cancer, Non-small cell; Malignancy; Medical prognosis; Monoclonal antibodies; Mutagenesis; Physiological aspects; Plasmids; Pluripotency; shRNA; siRNA; SOX2; Sox2 protein; Stem cell factor; Stem cells; Transcription factors; Tumors; South Korea; United States > US; SOX2; CRISPR/Cas9; shRNA; cancer stem cell-like properties; lung adenocarcinoma

Effectively targeting cancer stemness is essential for successful cancer therapy. Recent studies have revealed that , a pluripotent stem cell factor, significantly contributes to cancer stem cell (CSC)-like characteristics closely associated with cancer malignancy. However, its contradictory impact...