Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion

• Published in: Free radical biology & medicine Vol. 162; pp. 339 - 352
• Main Authors: Tang, Li-Jing, Zhou, Yuan-Jing, Xiong, Xiao-Ming, Li, Nian-Sheng, Zhang, Jie-Jie, Luo, Xiu-Ju, Peng, Jun
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2021
• Subjects: Animals; Ferroptosis; Heart; Ischemia; Ischemia/reperfusion; p53; Rats; Rats, Sprague-Dawley; Receptors, Transferrin; Reperfusion; Transferrin receptor 1; Tumor Suppressor Protein p53 - genetics; Ubiquitin-Specific Peptidase 7 - genetics; Ubiquitin-specific protease 7; Ferroptosis; Ischemia/reperfusion; Ubiquitin-specific protease 7; Transferrin receptor 1; p53

Iron overload triggers the ferroptosis in the heart following ischemia/reperfusion (I/R) and transferrin receptor 1 (TfR1) charges the cellular iron uptake. Bioinformatics analysis shows that the three molecules of ubiquitin-specific protease 7 (USP7), p53 and TfR1 form a unique pathway of USP7/p53/...