Glutathione S-Transferases M1 and P1 Prevent Aggravation of Allergic Responses by Secondhand Smoke

• Published in: American journal of respiratory and critical care medicine Vol. 174; no. 12; pp. 1335 - 1341
• Main Authors: Gilliland, Frank D, Li, Yu-Fen, Gong, Henry, Jr, Diaz-Sanchez, David
• Format: Journal Article
• Language: English
• Published: New York, NY Am Thoracic Soc 15.12.2006; American Lung Association; American Thoracic Society
• Subjects: Adult; Air cleanliness; Allergens; Allergic diseases; Allergies; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antioxidants; Asthma; Biological and medical sciences; Cross-Over Studies; D. Environmental and Occupational Lung Disease; Female; General aspects; Genotype; Glutathione S-Transferase pi - genetics; Glutathione S-Transferase pi - physiology; Glutathione Transferase - genetics; Glutathione Transferase - physiology; Hay fever; Histamine; Histamine - analysis; Humans; Immunoglobulin E - analysis; Immunopathology; Intensive care medicine; Interferon-gamma - analysis; Interleukin-4 - analysis; Male; Medical sciences; Middle Aged; Other localizations; Oxidative stress; Pollutants; Respiratory Hypersensitivity - genetics; Respiratory Hypersensitivity - physiopathology; Rhinitis; Tobacco smoke; Tobacco Smoke Pollution - adverse effects; Vehicle Emissions - toxicity; Immunopathology; Allergy; Histamine; Intensive care; Tobacco; Enzyme; Glutathione transferase; Transferases; IgE; GSTM1; GSTP1; histamine; IgE; tobacco smoke; Resuscitation

Secondhand tobacco smoke (SHS) and traffic-related air pollutants are associated with asthma and allergy. Diesel exhaust particles (DEPs) and SHS can interact with allergens in exacerbating allergic airway diseases through generation of reactive oxygen species. Glutathione S-transferases (GSTs) meta...