Population pharmacokinetic/pharmacodynamic modeling and exposure-response analysis of ciprofol in the induction and maintenance of general anesthesia in patients undergoing elective surgery: A prospective dose optimization study

• Published in: Journal of clinical anesthesia Vol. 92; p. 111317
• Main Authors: Liu, Lu, Wang, Kun, Yang, Yuting, Hu, Mengyue, Chen, Meixia, Liu, Xiao, Yan, Pangke, Wu, Nan, Xiang, Xiaoqiang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2024; Elsevier Limited
• Subjects: Anesthesia; Anesthesia, General - adverse effects; Anesthetics, Intravenous - adverse effects; Body Weight; Ciprofol; Clinical outcomes; Clinical trials; Drug dosages; Elective surgery; General anesthesia; HSK3486; Humans; Infusions, Parenteral; Intensive care; Normal distribution; Pain Medicine; Parameter estimation; Patients; Pharmacokinetics; PK-PD; Propofol; Prospective Studies; Variance analysis; United States > US; China; General anesthesia; Ciprofol; HSK3486; PK-PD; Elective surgery

This study aimed to establish a population pharmacokinetic and pharmacodynamic (PK-PD) model to explore the optimal maintenance dose and appropriate starting time of maintenance dose after induction of ciprofol and investigate the efficacy and safety of ciprofol for general anesthesia induction and...