Molecular Mechanisms Underlying Loss of Vascular and Epithelial Integrity in Irritable Bowel Syndrome

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 167; no. 6; pp. 1152 - 1166
• Main Authors: Barbaro, Maria Raffaella, Cremon, Cesare, Marasco, Giovanni, Savarino, Edoardo, Guglielmetti, Simone, Bonomini, Francesca, Palombo, Marta, Fuschi, Daniele, Rotondo, Luca, Mantegazza, Giacomo, Duncan, Robin, di Sabatino, Antonio, Valente, Sabrina, Pasquinelli, Gianandrea, Vergnolle, Nathalie, Stanghellini, Vincenzo, Collins, Stephen M., Barbara, Giovanni
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2024; Elsevier
• Subjects: Cellular Biology; Endocrinology and metabolism; Food and Nutrition; Gut Vascular Barrier Permeability; Histone Deacetylase; Human health and pathology; Intestinal Barrier Permeability; Life Sciences; Plasmalemma Vesicle–Associated Protein 1; Protease-Activated Receptor 2; Subcellular Processes; Vascular Endothelial Cadherin; CD; AST; Protease-Activated Receptor 2; HDAC11; Plasmalemma Vesicle–Associated Protein 1; iPAR; ALT; Intestinal Barrier Permeability; PV1; L/M; UC; Histone Deacetylase; Gut Vascular Barrier Permeability; GVB; IBS-D; IBS-C; PAR2; VEC; Vascular Endothelial Cadherin; HRQOL; HUVEC; IBS-M; IBS; Associated Protein 1; Protease-Activated Receptor2; Plasmalemma Vesicle-Associate

The pathophysiology of irritable bowel syndrome (IBS) is multifactorial and includes epithelial barrier dysfunction, a key element at the interface between the gut lumen and the deeper intestinal layers. Beneath the epithelial barrier there is the vascular one representing the last barrier to avoid...