Comprehensive Analysis of Chemotherapeutic Agents That Induce Infectious Neutropenia

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 14; no. 7; p. 681
• Main Authors: Okunaka, Mashiro, Kano, Daisuke, Matsui, Reiko, Kawasaki, Toshikatsu, Uesawa, Yoshihiro
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 15.07.2021; MDPI
• Subjects: Antibiotics; Bacterial infections; cancer; Cancer therapies; Cell division; chemotherapeutic agent; Chemotherapy; chemotherapy-induced neutropenia; Cluster analysis; Cytotoxicity; Drug dosages; Infections; Inflammatory bowel disease; Kinases; Monoclonal antibodies; Neutropenia; Neutrophils; Principal components analysis; Proteins; Risk factors; Sepsis

Chemotherapy-induced neutropenia (CIN) has been associated with a risk of infections and chemotherapy dose reductions and delays. The chemotherapy regimen remains one of the primary determinants of the risk of neutropenia, with some regimens being more myelotoxic than others. Although a number of cl...