GSTM1 null and NAT2 slow acetylation genotypes, smoking intensity and bladder cancer risk: results from the New England bladder cancer study and NAT2 meta-analysis

• Published in: Carcinogenesis (New York) Vol. 32; no. 2; pp. 182 - 189
• Main Authors: Moore, L. E., Baris, D. R., Figueroa, J. D., Garcia-Closas, M., Karagas, M. R., Schwenn, M. R., Johnson, A. T., Lubin, J. H., Hein, D. W., Dagnall, C. L., Colt, J. S., Kida, M., Jones, M. A., Schned, A. R., Cherala, S. S., Chanock, S. J., Cantor, K. P., Silverman, D. T., Rothman, N.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.02.2011
• Subjects: Acetylation; Adult; Aged; Arylamine N-Acetyltransferase - genetics; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; Case-Control Studies; Female; Genotype; Glutathione Transferase - genetics; Humans; Male; Medical sciences; Middle Aged; Molecular Epidemiology; Nephrology. Urinary tract diseases; Risk; Smoking - adverse effects; Tobacco, tobacco smoking; Toxicology; Tumors; Tumors of the urinary system; Urinary Bladder Neoplasms - etiology; Urinary Bladder Neoplasms - genetics; Urinary system involvement in other diseases. Miscellaneous; Urinary tract. Prostate gland; England; United Kingdom; Great Britain; Europe; Acyltransferases; Urinary system disease; Enzyme; Isozyme; Transferases; Intensity; Tobacco smoking; Genotype; Arylamine N-acetyltransferase; Urinary tract disease; Malignant tumor; Bladder cancer; Metaanalysis; Glutathione transferase; Risk factor; Bladder disease; Acetylation; Cancer

Associations between bladder cancer risk and NAT2 and GSTM1 polymorphisms have emerged as some of the most consistent findings in the genetic epidemiology of common metabolic polymorphisms and cancer, but their interaction with tobacco use, intensity and duration remain unclear. In a New England pop...