Identification of Xenopus cyclin-dependent kinase inhibitors, p16Xic2 and p17Xic3

• Published in: Gene Vol. 342; no. 1; pp. 41 - 47
• Main Authors: Daniels, Maki, Dhokia, Vishal, Richard-Parpaillon, Laurent, Ohnuma, Shin-ichi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.11.2004
• Subjects: Amino Acid Sequence; Animals; Carrier Proteins - genetics; Cell Cycle - drug effects; Cell cycle regulation; Cell Division - drug effects; Cell fate determination; Cloning, Molecular; Cyclin-dependent kinase inhibitor; Cyclin-Dependent Kinase Inhibitor Proteins; Cyclin-Dependent Kinases - antagonists & inhibitors; Cyclin-Dependent Kinases - metabolism; DNA, Complementary - chemistry; DNA, Complementary - genetics; DNA, Complementary - isolation & purification; Embryo, Nonmammalian - cytology; Embryo, Nonmammalian - drug effects; Embryo, Nonmammalian - metabolism; Female; Gene Expression Regulation, Developmental; In Situ Hybridization; Male; Microinjections; Molecular Sequence Data; Phylogeny; Retina; RNA, Messenger - administration & dosage; RNA, Messenger - genetics; RNA, Messenger - metabolism; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Time Factors; Xenopus laevis; Xenopus laevis - embryology; Xenopus laevis - genetics; Xenopus Proteins - genetics; PCNA; Xenopus laevis; Retina; cdk; Cell fate determination; ODC; GFP; pGFP; Cyclin-dependent kinase inhibitor; RT-PCR; RACE; Cell cycle regulation; MBT

The Cip/Kip family of mammalian cyclin-dependent kinase (cdk) inhibitors plays important roles in development, particularly in cell fate determination and differentiation, in addition to their function of blocking cell cycle progression. We have identified two novel members of the Kip/Cip cdk inhibi...