SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

• Published in: Science (American Association for the Advancement of Science) Vol. 370; no. 6523; pp. 1464 - 1468
• Main Authors: Hou, Yixuan J., Chiba, Shiho, Halfmann, Peter, Ehre, Camille, Kuroda, Makoto, Dinnon, Kenneth H., Leist, Sarah R., Schäfer, Alexandra, Nakajima, Noriko, Takahashi, Kenta, Lee, Rhianna E., Mascenik, Teresa M., Graham, Rachel, Edwards, Caitlin E., Tse, Longping V., Okuda, Kenichi, Markmann, Alena J., Bartelt, Luther, de Silva, Aravinda, Margolis, David M., Boucher, Richard C., Randell, Scott H., Suzuki, Tadaki, Gralinski, Lisa E., Kawaoka, Yoshihiro, Baric, Ralph S.
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 18.12.2020; American Association for the Advancement of Science
• Subjects: ACE2; Amino Acid Substitution; Angiotensin-converting enzyme 2; Angiotensin-Converting Enzyme 2 - genetics; Animal models; Animals; Asparagine - genetics; Aspartic acid; Coronaviridae; Coronaviruses; COVID-19; COVID-19 - transmission; COVID-19 - virology; Cricetinae; Disease transmission; Fitness; Genetic Fitness - genetics; Glycine; Glycine - genetics; Hamsters; Humans; Mesocricetus; Mice; Mice, Transgenic; Microbio; Morphology; Mutation; Neutralization; Pandemics; Pathogenesis; Pathogens; Replication; Respiratory diseases; Respiratory Mucosa - virology; Rodents; SARS-CoV-2 - genetics; SARS-CoV-2 - pathogenicity; Severe acute respiratory syndrome coronavirus 2; Substitutes; Viral diseases; Virulence; Virulence - genetics; Virus Replication - genetics; Viruses

Pandemic spread of a virus in naïe populations can select for mutations that alter pathogenesis, virulence, and/or transmissibility. The ancestral form of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged from China has now been largely replaced by strains containing the muta...