Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence

• Published in: Cancers Vol. 12; no. 10; p. 3034
• Main Authors: Di Sotto, Antonella, Mancinelli, Romina, Gullì, Marco, Eufemi, Margherita, Mammola, Caterina Loredana, Mazzanti, Gabriela, Di Giacomo, Silvia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.10.2020; MDPI
• Subjects: Antitumor agents; Apoptosis; Cancer; Cancer therapies; Carcinogens; Caryophyllene; Caryophyllene oxide; Cell cycle; Chemoprevention; Chemopreventive agents; Clinical trials; DNA damage; Drugs; Essential oils; Gene expression; Humulene; Marine environment; Methods; Oils & fats; Phytochemicals; Review; Sesquiterpenes; Toxicity; Italy; β-caryophyllene; β-caryophyllene oxide; Nrf2; membrane permeability; STAT3; genoprotection; α-humulene; apoptosis; ABC transporters; isocaryophyllene

Chemoprevention is referred to as a strategy to inhibit, suppress, or reverse tumor development and progression in healthy people along with high-risk subjects and oncologic patients through using pharmacological or natural substances. Numerous phytochemicals have been widely described in the litera...