Endothelin-1 myocardial clearance, production, and effect on capillary permeability in vivo

• Published in: The American journal of physiology Vol. 273; no. 3 Pt 2; p. H1239
• Main Authors: Dupuis, J, Goresky, C A, Rose, C P, Stewart, D J, Cernacek, P, Schwab, A J, Simard, A
• Format: Journal Article
• Language: English
• Published: United States 01.09.1997
• Subjects: Animals; Capillary Permeability - drug effects; Capillary Permeability - physiology; Diastole - drug effects; Dogs; Endothelin-1 - biosynthesis; Endothelin-1 - pharmacokinetics; Endothelin-1 - pharmacology; Heart Rate - drug effects; Hemodynamics - drug effects; Hemodynamics - physiology; Kinetics; Metabolic Clearance Rate; Models, Cardiovascular; Myocardium - metabolism; Systole - drug effects; Time Factors

Myocardial metabolism of endothelin-1 (ET-1) and its effect on coronary microcirculatory exchanges were obtained in anesthetized dogs by combining the indicator-dilution technique with immunoreactive ET-1 measurements. The myocardium extracted 17.7 +/- 4.6% of tracer ET-1 (n = 12). Simultaneously me...